本文综述了细胞凋亡的调控与心血管疾病的关系及抗凋亡的药物。
Modulating of cell apoptosis, relation between the apoptosis and cardiovascular diseases and the drugs against apoptosis were reviewed in this article.
教授比斯蒂挑出“藏红花的'抗凋亡的财产-的能力,增加氧气供应的身体和防止细胞死亡,”作为其有益作用的关键因素。
Professor Bisti singled out "saffron's 'anti-apoptotic' properties - its ability to increase the availability of oxygen to the body and prevent cell death," as a key factor in its beneficial effects.
方法和结果—我们首次研究了巨噬细胞抗凋亡能力对早期及晚期动脉粥样硬化斑块的定向保护效应。
Methods and Results - We first evaluated the impact of targeted protection of macrophages against apoptosis at both early and advanced stages of atherosclerosis.
此外,脐血干细胞还有明显的抗凋亡作用。
In addition, the umbilical cord blood stem cells have significant anti-apoptosis effect.
机制尚不清楚,但其抗炎作用可能改变了组织坏死和细胞凋亡在细胞损伤中所占的比例。
The mechanism of improved tissue viability is unclear, but the anti-inflammatory effects may alter the relative contribution of tissue necrosis versus apoptosis to cellular injury.
结论抗凋亡蛋白肽高剂量预处理对脂多糖诱导的大鼠肺损伤有保护作用。
Condusion High-dose anti - apoptotic peptide have a protective effect on LPS-induced acute lung injury in rats.
对于筛选出的三种抗脱落凋亡的肿瘤细胞系,它们的抗脱落凋亡特性究竟与哪个或哪些信号分子有关呢?
Next we tried to find out which signaling molecules in the selected three tumor cell lines are related to their resistance to anoikis.
结果:两种药物均具有抗qgy细胞增殖、阻滞细胞周期、诱导凋亡及抑制端粒酶活性的作用。
Results: These two drugs could inhibit the proliferation of QGY cells, block the cell cycle, induce its apoptosis and inhibit the activity of telomerase.
研究南蛇藤总萜体外抑制鼠黑色素瘤B16BL6细胞增殖,以及对其细胞凋亡的影响,为南蛇藤总萜对黑色素瘤抗瘤活性方面的研究奠定初步基础。
To study the effect of celastrus orbiculatus terpenoid on mouse melanoma B16BL6 cell proliferation and apoptosis in vivro and to establish its foundation in aspect of antitumor activity to melanoma.
目的:探讨糖网明对糖尿病大鼠视网膜神经细胞的抗凋亡作用及其可能的机理。
Objective: to explore the anti - apoptosis effect and mechanism of tangwangming on retinal neural cells in diabetic rats.
消减免疫法有助于制备抗在凋亡细胞高表达,而在非凋亡细胞低表达或不表达的凋亡相关抗原的抗体。
Subtractive immunization is helpful for preparing the antibodies against the apoptosis-associated antigens which expresses highly in apoptotic cells, but lowly or barely in non-apoptotic cells.
结论:饮食调整和运动均能诱导糖尿病大鼠的心肌抗凋亡基因的表达,饮食调整加低强度耐力运动效果尤为显著;
Conclusion:Diet and endurance training, especially diet plus low intensity exercise, can improve the expression of antiapoptotic gene in cardiac muscles of diabetic rats.
目的:观察抗喘胶囊对哮喘大鼠肺泡灌洗液嗜酸性粒细胞凋亡的影响。
Objective: to observe the effect of KangChuan capsule on Eosinophils apoptosis of bronchoalveolar lavage fluid (BALF) in asthma model rats.
细胞凋亡的出现较晚,可能使抗凋亡成为治疗脑梗死的一种有效的途径之一。
Anti apoptosis may be one of significant methods for treating cerebral infarction because of delayed apoptosis.
热休克蛋白(HSP)对细胞凋亡有双向调控作用,尤其是其抗细胞凋亡的作用为临床多种疾病的治疗开辟了新的途径。
Heat shock protein(HSP) shows both biological effects of up-regulation and down-regulation on apoptosis. Especially the suppressive effects on apoptosis provide a new path to treat various diseases.
结论氨茶碱可能通过抑制肺组织TRAIL的表达来抑制TRAIL的促炎作用,同时还可以通过促进哮喘大鼠气道的T淋巴细胞凋亡发挥抗炎作用。
Conclusion Aminophyline could inhibit the inflammation of asthmatic airway by reducing the expression of TRAIL in rat lung and promoting the apoptosis of T-lymphocytes in asthmatic rat airway.
原癌基因的激活,抑癌基因的失活、突变,抗细胞凋亡等不同的机制都可能参与其中。
The different mechanisms, such as the activation of oncogenes, the inactivation and mutation of tumor suppressor gene, antiapoptosis and so on are involved in .
有学者认为,凋亡可能是全身炎症反应中调节致炎、抗炎反应平衡的关键因素。
It is considered that apoptosis may represent a key factor in modulating the balance between inflammatory and anti-inflammatory response during systemic inflammation.
结论苦参碱可抑制HSC增殖、诱导HSC凋亡,可能是苦参碱抗肝纤维化的机制之一。
Conclusion matrine can inhibit HSC proliferation and induce apoptosis of HSC, which might be one of the mechanisms of matrine to counteract liver fibrosis.
目的观察抗VEGF抗体对K562细胞凋亡的影响,探讨VEGF抑制白血病细胞凋亡的机理。
Objective To study the effect and mechanism of anti-VEGF antibody on apoptosis of K562 cells.
目的:研究粉防己碱与长春新碱合用能否逆转人乳腺癌M CF 7多药耐药细胞的抗凋亡作用。
Objective: to study whether the anti-apoptotic action is reversed by tetrandrine in a combination with vincristine in human breast carcinoma MCF-7 multidrug-resistant cells.
正>目的:观察:BDNF对涎腺腺样囊性癌细胞系增殖和抗失巢凋亡能力的影响,揭示BDNF与涎腺腺样囊性癌高转移特性的关系。
Objective: To observe the effect of BDNF on the proliferation and anoikis resistance of Salivary gland adenoid cystic carcinoma (SACC) cell line in vitro.
胰岛素受体自身酪氨酸磷酸化抑制剂一一HNMPA一AM3可以阻断胰岛素的抗凋亡作用。
HNMPA-AM3 -the insulin receptor tyrosine kinase inhibitor could block the anti-apoptosis effect of insulin.
结论(1)控制性再灌注有较好的抗神经元细胞凋亡和神经恢复功能作用;
Conclusions (1)CR can effectively increase antiapoptotic gene expression of hippocampus CA region and play an important role in the neural rehabilitation.
抗凋亡方面是一个关键因素生存的一种恶性肿瘤细胞。
Resistance towards apoptosis is a key factor for the survival of a malignant cell.
表明富含腺嘌呤类衍生物的玉米幼芽提取物对体外培养的小鼠皮肤成纤维细胞具有抗凋亡保护作用,在细胞氧化损伤过程中,对细胞膜蛋白和结构性蛋白有保护作用。
Above all, extracts of maize plumule rich in adenine ramification could prevent MDF from apoptosis, and protect the structure protein and membrane protein when the oxidative damage happened.
目的探讨麦冬药物血清抗血管内皮细胞凋亡的分子机制。
OBJECTIVE to investigate into the molecular mechanism of the pharmacological serum of Radix Ophiopogonis against the apoptosis of vascular endothelial cell.
尽管几个研究清楚地把HAX - 1界定为一种抗凋亡蛋白,它发挥功能的机理仍然未知。
Although several studies clearly define HAX-1 as an anti-apoptotic protein, the mechanism of its function is unknown.
实验研究发现其具有抗转移、诱导肿瘤细胞凋亡、影响细胞信号转导以及预防肝癌发生的作用。
Experimental studies have showed its effects in inhibiting metastases, apoptotic induction, cell signal transduction and prevention of liver carcinogenesis.
介绍褪黑素的合成、代谢通路及其抗氧化、抗细胞凋亡等神经保护作用。
The pathway of synthesis and metabolism, and neuron-protective effect of melatonin were introduced.
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