方法和结果—我们首次研究了巨噬细胞抗凋亡能力对早期及晚期动脉粥样硬化斑块的定向保护效应。
Methods and Results - We first evaluated the impact of targeted protection of macrophages against apoptosis at both early and advanced stages of atherosclerosis.
巨噬细胞是动脉粥样硬化的发病机制的组成部分，在炎症和胆固醇平衡运作，其生物学特性的一个重要课题。
The macrophage is integral to the pathogenesis of atherosclerosis, functioning at the intersection of inflammation and cholesterol homeostasis, making its biological properties an important topic.
症状包括胰岛素抵抗增加、动脉粥样硬化和能够刺激免疫防御细胞-巨噬细胞的高水平信号分子。
Symptoms included increased insulin resistance and atherosclerosis and higher levels of a signaling molecule that activates a class of immune defensive cells known as macrophages.
抑制巨噬细胞源泡沫细胞中脂质聚积、减轻炎症反应可能有动脉粥样硬化预防、治疗价值。
Inhibiting lipid accumulation in macrophage-derived foam cells and reduce inflammatory responses may be of therapeutic value in preventing coronary artery disease.
另一个最常见的白细胞是巨噬细胞，它是象嗜中性白细胞一样的噬菌细胞，有着很多其他的防御功能。
The next most common milk leukocyte is the macrophage, which is phagocytic like neutrophils and performs a number of other protective functions.
结论辛伐他汀与罗格列酮均能降低血脂，并通过降低巨噬细胞CD 40和CD 40l表达发挥抗动脉粥样硬化作用。
Conclusion Simvastatin and rosiglitazone can decrease serum level of lipids and exert anti-atherosclerotic effect by reducing the expression of CD40 and CD40L.
血管壁中巨噬细胞产生脂蛋白脂酶，使脂质积聚于动脉壁内，促进动脉粥样硬化进展。
Macrophages constitutively synthesize LPL, which may contribute to lipid accumulation within the arterial wall, promoting the atherogenic process.
高倍镜下可见粥样斑块中有许多泡沫细胞(即吞噬大量脂质的巨噬细胞)和胆固醇结晶。
At higher magnification, many foam cells (macrophages full of lipid material) and a cholesterol cleft are seen in this atheromatous plaque.
描述了巨噬细胞演变为上皮样细胞、纤维母细胞样细胞和成纤维细胞的过程。
Phagocytic particles were in the cytoplasm of fibroblast like cells, epithelioid cells and macrophages.
肉芽肿由巨噬细胞而来的上皮样细胞，以及少量淋巴细胞，中性粒细胞，浆细胞，成纤维细胞组成。
Granulomas are composed of transformed macrophages called epithelioid cells along with lymphocytes, occasional PMN's, plasma cells, and fibroblasts.
研究发现组织因子(TF)位于血管外膜和粥样斑块的脂质中心，并特异地表达于单核细胞和巨噬细胞膜表面。
Tissue factor (TF) is found in the adventitia of blood vessels and in the lipid core of atherosclerotic plaques, and is specifically expressed on monocyte or macrophage cell membrane surfaces.
MMP-2在粥样硬化冠脉斑块中有表达，表达的阳性部位为内膜的血管内皮细胞胞浆、巨噬细胞胞浆、平滑肌细胞胞浆和中膜的平滑肌细胞胞浆。
MMP-2 protein expression can be observed in atherosclerosis, mainly in macrophage, foam cells, endothelial cell, smooth muscle cell in endomembrane, smooth muscle cell and fibrocyre in tunica media.
抑制巨噬细胞炎性细胞因子的分泌有助于治疗动脉粥样硬化及其临床并发症。
Inhibiting the secretion of macrophage inflammatory cytokine is good for healing atherosclerosis and its clinical complications.
抑制巨噬细胞炎性细胞因子的分泌有助于治疗动脉粥样硬化及其临床并发症。
Inhibiting the secretion of macrophage inflammatory cytokine is good for healing atherosclerosis and its clinical complications.
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