这也引出一项新的技术——基因靶向技术。
但是他们各自所研究的细胞类型不能用来培育基因靶向动物。
But the kinds of cells they independently studied could not be used to create gene-targeted animals.
基因靶向技术的进步，带来了人类改造生命的可能。
Gene targeting technology, has brought the possibility of human transformation of life.
另外免疫调节、基因靶向治疗为其提供了新的治疗思路。
And immunological regulators and gene targeting treatment are new ways for treatment.
肿瘤靶向基因治疗的主要目的是用靶向性的载体将治疗基因靶向传递到肿瘤细胞。
A major goal of tumor-targeting gene therapy is to transfer genes efficiently to tumor cells by targeted vectors.
通过基因靶向疗法研究者们将产生ERα的基因传递入海马，维持小鼠的学习能力。
However, scientists were still able to rescue learning ability by delivering the correct gene to produce estrogen receptor-alpha directly to the hippocampus.
科学家们发现“30%-40%乳腺癌存活者表达乳腺癌相关基因，这些基因可能是这些患者基因靶向治疗最大的靶标”。
Scientists have discovered a breast cancer gene 30% to 40% of all breast cancers need to survive, offering what could be the biggest gene target yet for "smart bombs" to treat such tumours.
针对不吸烟者的基因改变进行靶向治疗，这有些其它的成功例子，比如针对有EML4-ALK基因改变的肿瘤进行的治疗。
There are other examples of success in specifically targeting genetic changes in never-smokers with lung cancer, such as treatments of tumors with alterations in the EML4-ALK gene.
有一些“候选基因”与已知基因是一致的，有些则不然，因此该研究计划下一步对基因组中SNP靶向区域进行研究，以求找出其中所可能具有的遗传特性。
Some of the candidates corresponded to known genes. Others did not, and the next phase of the project will be to search the areas of the genome that the SNPs point at for likely genetic suspects.
以往我们曾经使用基因疗法，对大脑进行靶向治疗，最后我们发现可能存在一种药物，它可以单独作用于大脑，增强这条信号通路。
We used a gene therapy technique that enables us to target the brain, but ultimately there could be a pharmaceutical that enhances the signaling pathway solely in the brain.
如果这种方法在人体有作用，就将提供一种高度靶向抗癌基因治疗的新方法。
If it works in people, it would provide a highly targeted mechanism for delivering cancer-fighting gene therapy.
这些酶名为锌脂蛋白核算酶，可在实验室内加工后靶向作用于特定基因，引入序列改变，获得希望得到的特性。
The enzymes — known as zinc finger nucleases — can be engineered in the lab to target specific genes, introducing changes known to cause the desired trait.
曲妥珠单抗是一种人源化抗体，用于靶向和阻断her2的功能，而后者是由特异基因编码的一种蛋白，具有致癌潜能。
Trastuzumab is a humanised antibody, designed to target and block the function of HER2, a protein produced by a specific gene with cancer-causing potential.
基于该技术设计的首批靶向基因的药物已经在美国开始临床试验了，主要是针对具有动脉疾病和由糖尿病引发的神经损伤的病人。
The first drugs designed to target the genes have begun clinical trials in the United States on patients with arterial disease and diabetes-induced nerve damage.
目的介绍目前关于肝癌基因治疗靶向性研究的进展。
Objective To review the advances of target gene therapy of liver cancer.
目的探讨乙型肝炎病毒（HBV）作为肝靶向性基因治疗载体的可能性。
Objective To evaluate the possibility of hepatitis B virus (HBV) as a vector in liver-targeting gene therapy.
近年来，肝靶向性基因治疗取得了很大的进展。
In recent years, hepatocyte-targeted gene therapy made a rapid progress.
结果纳米颗粒转运系统能够保护被转运的基因，有较高的转染效率，具有良好的靶向性，并且提高了药物的生物利用度，显示出一定的缓控释作用。
Results Nanoparticle carrier system can protect the genes, have a high carrying efficiency and a well targeting property, it also can improve the bioavailability, sustained and controlled release.
目的：研究TRAIL基因结合端粒酶启动子特异性靶向治疗的作用。
AIM: To explore targeted gene therapy of tumor by using the combination of TRAIL gene with the telomerase promoter.
这种靶向性的策略包括目的基因对肿瘤细胞的靶向转移，目的基因在肿瘤细胞中的特异表达，以及基因修饰细胞分泌的肿瘤靶向治疗分子。
This can be achieved by tumor targeted gene transfer or tumor specific gene expression, as well as secretion of tumor targeted therapeutic molecules by autologous normal cells.
用小分子靶向转录因子以调节特定基因的表达是众所周知难以实现的。
Targeting transcription factors with small molecules to modulate the expression of certain genes has been notoriously difficult to achieve.
靶向基因治疗在化疗过程中取得明显效果，现将近年来靶向基因治疗急性淋巴细胞白血病的研究进展综述如下。
Targeted gene therapy in the course of chemotherapy has achieved remarkable results, now in recent years, targeted gene therapy of acute lymphoblastic leukemia research are summarized below.
结论GE7基因治疗系统能够达到靶向性治疗垂体腺瘤的目的。
Conclusion GE7 system-mediated gene therapy system can transfer target gene to pituitary adenoma effectively and specifically.
近几年，国内外学者利用超声联合微泡造影技术所产生的生物学效应，实现了微泡造影剂携载药物和基因对肿瘤的靶向治疗。
Resently years, researchers utilize biological effects generated by microbubble contrast agent combined ultrasound techniques to implement therapy of tumor by microbubble carrying drug and gene.
有效并且安全的靶向性载体是基因治疗能否成功的关键。
Effective and secure targeted vector is the key of the gene therapy succeed or not.
病毒载体的靶向性问题是肿瘤基因治疗中的重要研究热点，靶向病毒载体是提高肿瘤基因治疗安全性和有效性的重要途径。
Vector tropism is a research hot spot in cancer gene therapy, and targeted viral vectors play a key role in the enhancement of safety and efficiency in cancer gene therapy.
因此，XAF1是一个新的肿瘤抑制基因，有可能成为肿瘤治疗的新靶向基因。
Thus XAF1 is a new cancer inhibiting gene and may become a new target to treat carcinoma.
针对CXCR4靶向治疗将成为肿瘤基因治疗研究的新热点。
CXCR4-targeted therapeutic approaches will become a new hot point in the research of tumor gene therapy.
KRAS基因突变在恶性肿瘤组织中频发，可预测非小细胞肺癌分子靶向治疗的疗效和预后，针对RAS基因的分子抑制剂研究仍处于初级阶段。
KRAS mutation frequency in tumor tissue, can be predicted non-small cell lung cancer molecular targeted therapy efficacy and prognosis, and molecular inhibitors of RAS genes is still in its infancy.
目的构建并评价受体靶向性基因导入系统对垂体腺瘤的靶向性治疗作用。
Objective to construct and evaluate the receptor targeted gene therapy system for pituitary adenoma.
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