激活基因表达或使基因表达失活的化学诱导系统在确定基因功能及植物生物技术中有许多潜在的应用。
Chemically inducible systems that activate or inactivate gene expression have many potential applications in the determination of gene function and in plant biotechnology.
这种现象主要在印迹基因和X染色体失活区域看到，这些区域中的启动子区的DNA甲基化导致了基因表达的抑制。
This phenomenon is mostly seen in imprinted genes and X-chromosome inactivation where DNA methylation of promoter regions leads to repression of gene expression.
探讨这些基因逃避X失活的机制有助于理解X染色体失活是如何对基因表达进行调控的。
Study on the mechanisms of 'escape' is helpful to the understanding of gene regulation by X inactivation.
建立于目标基因激活和失活基础之上的几个化学分子诱导基因表达系统已有报道。
Various chemical inducible systems based on activation and inactivation of the target gene had been described.
结论3例FA-A型患者均无功能性FANCA蛋白表达；基因缺失、移码突变和剪切位点突变是FANCA基因的主要失活方式。
Conclusions No functional FANCA protein was found in these 3 cases of FA-A, and intragenic deletion, frame shift and splice site mutation were the major pathogenic mutations found in FANCA gene.
结论3例FA-A型患者均无功能性FANCA蛋白表达；基因缺失、移码突变和剪切位点突变是FANCA基因的主要失活方式。
Conclusions No functional FANCA protein was found in these 3 cases of FA-A, and intragenic deletion, frame shift and splice site mutation were the major pathogenic mutations found in FANCA gene.
应用推荐