在翻译水平上也存在着引起基因失活的可能机制。
There may exist a mechanism at gene translation level which leads to the inactivation of the p16 and Rb genes.
这种染色体异常使控制细胞生长的关键肿瘤抑制基因失活。
Such chromosomal abnormalities inactivate tumor - suppressor genes that are critical for controlling cell growth.
甲基化机制可能是肝细胞癌runx3基因失活的重要机制之一。
DNA methylation may be an important mechanism of inactivation of RUNX3 gene in HCC.
P 53基因失活与慢性粒细胞白血病的急变、病情进展密切相关。
The inactivation of P53 is associated with the acute transformation phase and development of CML.
FHIT基因失活与吸烟相关，但与组织学类型、分化程度、临床分期和转移无关。
The loss of FHIT expression did not correlate with histological type, cell differentiation, clinical stage and metastasis, but was frequently observed in tobacco smokers.
肿瘤的发生是原癌基因激活、抑癌基因失活以及凋亡相关基因失调等诸多因素综合作用的结果。
The development of tumor results from complex action among multiple factors such as oncogene activation, anti-oncogene inactivation, disturbance of apoptosis related gene and so on.
研究表明几乎一半人类肿瘤都存在抑癌基因的失活，可见抑癌基因失活与肿瘤生长有着密切的关系。
Studies have sh own that the anti oncogene inactivation was closely related to tumor development because of the findings of anti oncogene inactivation in nearly one half of human tumors.
BRCA - 1相关蛋白(BAP1)是一种肿瘤抑制基因，约半数的间皮瘤中显示双等位基因失活。
BRCA-1-associated protein (BAP1) is a tumor suppressor gene, which shows biallelic inactivation in approximately half of all mesotheliomas.
结果：AL LP16基因高度甲基化或纯合缺失发生率为80 % ，而对照组无一例P16基因失活；
Results:In ALL, the incidence of P16 hypermethylation or homozygous deletion is 80%, there is no abnormal in control.
有些人猜想，如其说染色体将使基因有活性和失活的蛋白质做上特定的基因标记，倒不如说染色体调整形状使基因与蛋白质靠近。
Some suspect that, rather than sending gene-activating and gene-stifling proteins to particular gene targets, chromosomes adjust their shape in order to bring genes closer to the proteins.
新方法现在允许某些时候研究人员直接显示那些基因由于组蛋白而被激活或失活。
New methods now allow researchers to sometimes directly show which genes have been activated or deactivated by the histones.
由于这些基因存在于X染色体上，它们发生了X染色体失活的处理。
Because these genes are carried on the X-chromosome, they are subject to a process known as X-chromosome inactivation.
最近在人和小鼠中发现了逃避X失活的基因。
The genes that escape X inactivation have been recently found in human and in mouse.
组蛋白H3第27位赖氨酸的甲基化与同源盒基因沉默、X染色体失活、基因印记等基因沉默现象有关；
The methylation of histone H3-K27 was proved to be linked to several silencing phenomena including homeotic-gene silencing, X inactivation and genomic imprinting.
探讨这些基因逃避X失活的机制有助于理解X染色体失活是如何对基因表达进行调控的。
Study on the mechanisms of 'escape' is helpful to the understanding of gene regulation by X inactivation.
杂合性丢失是基因一个拷贝的正常功能丢失，同时另一个拷贝已经失活。
LOH is usually defined as the loss of normalfunction of one copy of a gene in which the other copy was already inactivated.
这种现象主要在印迹基因和X染色体失活区域看到，这些区域中的启动子区的DNA甲基化导致了基因表达的抑制。
This phenomenon is mostly seen in imprinted genes and X-chromosome inactivation where DNA methylation of promoter regions leads to repression of gene expression.
结果表明，自我失活型逆转录病毒载体能很好地用于衰老基因转录调控的研究。
The results demonstrate that self-inactivating retrovirus vector can be used for gene transcription regulation research during the aging process.
激活基因表达或使基因表达失活的化学诱导系统在确定基因功能及植物生物技术中有许多潜在的应用。
Chemically inducible systems that activate or inactivate gene expression have many potential applications in the determination of gene function and in plant biotechnology.
例如，结果从一个白化突变失活的基因称为酪氨酸酶，这是至关重要的黑色色素的形成。
For example, albinism results from a mutation that inactivates a gene called tyrosinase, which is vital to black pigment formation.
目的探讨X-连锁迟发性脊椎骨骺发育不良（SEDL）基因逃避X染色体失活（XCI）及与临床表型的关系。
Objective To explore the relationship between X - linked spondyloepiphyseal dysplasia tarda (SEDL) gene escaping X chromosome inactivation( XCI) and SEDL phenotype.
结论人乳腺癌er基因的失活与其基因启动子高甲基化关系密切。
Conclusion the inactivation of er gene has a close relationship with the abnormal methylation of er gene promoter.
越来越多的证据表明，肿瘤的发生是多因素作用的结果，与癌基因的激活与抑癌基因的失活有关。
More and more evidence indicated that the formation of tumor is due to multi factors with oncogene activation and anti oncogene inactivation.
当这个基因被失活时，植物就不能再调节程序性细胞死亡过程，从而导致整个叶子和植物的死亡。
When the gene is inactivated, the plant can no longer regulate PCD, leading to cell death throughout the leaf and plant.
目前在分子水平上的研究显示肿瘤的发生与癌基因的激活和抑癌基因的失活以及细胞周期调节失控密切相关。
It has been proved that the occurrence of oncogenesis is in close relationship with the oncogene activation, the tumor suppressor gene inactivation and the disorder of cell cycle modulation.
建立于目标基因激活和失活基础之上的几个化学分子诱导基因表达系统已有报道。
Various chemical inducible systems based on activation and inactivation of the target gene had been described.
原癌基因的激活，抑癌基因的失活、突变，抗细胞凋亡等不同的机制都可能参与其中。
The different mechanisms, such as the activation of oncogenes, the inactivation and mutation of tumor suppressor gene, antiapoptosis and so on are involved in .
MGMT基因的失活常导致原癌基因的激活。
The inactivation of MGMT gene may urge the proto oncogene activation.
Venter称用人工合成的DNA完全替代生物体基因组就可以避免使干扰细胞预期功能的“讨厌的”DNA失活。
Venter said wholesale replacement of an organism's genome with synthetic DNA might avoid the need to disable undesirable genes that interfere with the cells' desired function.
Venter称用人工合成的DNA完全替代生物体基因组就可以避免使干扰细胞预期功能的“讨厌的”DNA失活。
Venter said wholesale replacement of an organism's genome with synthetic DNA might avoid the need to disable undesirable genes that interfere with the cells' desired function.
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