提示用叶酸或甲酰四氢叶酸钙后能保护复方硝喹对小肠的破坏，因而会大大减轻其临床毒性反应。
The results suggest that folic acid or folinic acid can protect the less differentiated cells in the intestinal crypts, so that the clinical manifestations of NQD toxicity are reduced after treatment.
目的探讨不同剂量四氢叶酸钙(CF)对大剂量甲氨蝶呤(HD -MTX)化疗大鼠肠黏膜的保护作用。
Objective To explore different doses of calcium 5-formyltetrahydrofolate (CF) for protecting enteral mucosa after chemotherapy of high-dose methotrexate (HD-MTX) in rats.
结论：进行甲氨蝶呤血药浓度监测有利于掌握好甲氨蝶呤和四氢叶酸钙的救援剂量，从而保证化疗的有效性和安全性。
CONCLUSIONS: MTX serum concentration monitoring is helpful for mastering the rational rescue dosage of MTX and calcium folinate so as to ensure the efficacy and safety of the chemotherapy.
结论：进行甲氨蝶呤血药浓度监测有利于掌握好甲氨蝶呤和四氢叶酸钙的救援剂量，从而保证化疗的有效性和安全性。
CONCLUSIONS: MTX serum concentration monitoring is helpful for mastering the rational rescue dosage of MTX and calcium folinate so as to ensure the efficacy and safety of the chemotherapy.
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