目的：为临床合理选用双膦酸盐类药物提供参考。
OBJECTIVE:To provide rational use of diphosphcmate preparations for reference.
双膦酸盐类药物，抑制破骨细胞，减轻许多破坏性后果骨转移疾病。
Bisphosphonates, which inhibit osteoclasts, alleviate many of the devastating consequences of metastatic bone disease.
绝经后骨质疏松症治疗中优化双膦酸盐类药物使用剂量和频率：病人的考虑。
Optimizing dosing frequencies for bisphosphonates in the management of postmenopausal osteoporosis: patient considerations.
方法：介绍双膦酸盐类药物的研究进展，对其在一些疾病中的应用进行了评价。
METHODS: to give account of research progress of diphosphonate preparations and to evaluate their application in some diseases.
目前双膦酸盐类药物治疗骨转移的主要目的是减少骨相关事件、减轻疼痛和提高生活质量。
The current aims of bi- sphosphonates for metastatic bone disease are to prevent skeletal-related events, reduce bone pain, and improve quality of life.
为进行这一试验，研究者们从23个国家招募了近2,000名没有服用过双膦酸盐类药物的患者。
For the study, researchers recruited about 2,000 patients from 23 countries who were not taking oral bisphosphonates.
为进行这一试验，研究者们从23个国家招募了近2,000名没有服用过双膦酸盐类药物的患者。
For the study, researchers recruited about 2,000 patients from 23 countries who were not taking oral bisphosphonates.
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