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It is very frequently associated with dermatitis herpetiformis, an itchy red raised rash with fluid-filled vesicles.
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Symptoms of shingles include groups of vesicles, or tiny blisters, on the skin along the nerves of the body.
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Development of many vesicles will occur, which join together, eventually rupturing, and forming an open ulcer, which, characteristically will develop a black eschar, which is like a scab.
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The circumstantial evidence is intriguing: as well as being more abundant in tumours than in ordinary cells, vaults, to Dr Scheper's eye, seem to congregate around the vesicles.
ECONOMIST: Cell biology: The secret of the vaults | The
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In the right conditions, an emulsion of these molecules will organise itself into small spheres, known as vesicles, that contain part of the liquid the phospholipids were suspended in.
ECONOMIST: Drug delivery
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And when Dr Anderson injected the modified vesicles into mice and then shone ultraviolet light of a wavelength that can pass through flesh at some of them, he found the tactic worked.
ECONOMIST: Drug delivery
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To both Dr Scheper and Dr Rome, this provides further proof that vaults are shuttles in this case carrying poisons from the nucleus to the vesicles that act as a cell's waste-disposal units.
ECONOMIST: Cell biology: The secret of the vaults | The
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The 100-nanometre vesicles produced no protein whatsoever.
ECONOMIST: Drug delivery