The defensive midfield pairing looked too cautious at times and vanBommel looked ill-equipped to get forward and support an attack that dominated for long periods of time.
Reynier vanBommel, the ninth-generation CEO of a family shoe company that bears his name, says the finishing process on its shoes has benefited from training he received in Italy.
Dutch enforcer Mark vanBommel was booked after going through the back of Iniesta, while Nigel de Jong was lucky to escape red after planting his foot in the chest of Xabi Alonso.
Van Persie is not the only player carrying an injury to be included in Van Marwijk's squad, with Liverpool's Dirk Kuyt, Mark vanBommel, Khalid Boulahrouz, Wout Brama, Eljero Elia, Theo Janssen and Ruud van Nistelrooy also called up.