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Rea will be joined on the grid by fellow British riders Craig Jones, Tommy Hill, Chris Walker and Graeme Gowland and is raring to go.
BBC: Jonathan Rea
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Prydie, from Porthcawl, has played just three times for the Ospreys, where he is behind established international stars Shane Williams, Tommy Bowe and Nikki Walker in the pecking order.
BBC: Wales' Tom Prydie 'can be a 2011 Rugby World Cup star'
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The Samoan took advantage after Gavin Henson's pass failed to reach Tommy Bowe and he skipped past a challenge from Walker to get the converted score and a 17-6 lead.
BBC: London Irish 23-19 Ospreys
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"I'm delighted with the foundations in place at this club, and I'm thankful to Tommy (Wright) for establishing that, " said Walker.
BBC: Walker named new Ballymena boss
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Tommy Bowe could face his former side while Scotland wing Nikki Walker scored a fine try in Dublin last week.
BBC: Holley hails Henson return boost