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They note that it hits only one unproven mechanism behind stroke and that it may be necessary to hit multiple biological pathways to get a significant effect.
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It is also worth noting that Lou Piniella and Joe Torre are the only two people that have accumulated 1, 700 hits during their playing careers and also won 1, 700 games as a manager.
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Those stratospheric price tags make blockbusters all the more important, and one worry is that some of the new drugs may be only moderate hits.
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For this is a wine that really only gets going at around 20 years in the bottle, hits its stride at 30 and can go on drinking for well beyond 100.
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However, 3, 000 hits places him in a pantheon of baseball excellence that is only inhabited by immortals and some of the greatest ball players that have ever lived.
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Some continue to call for a shot clock, mandatory tiebreakers in fifth sets (the U.S. Open is the only Slam that does this) and playing service lets (if a serve hits the net and goes in the correct box, it counts).
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Plenty of shows that went on to become hits struggled to find their audience at first, succeeding only because someone at the network showed faith and patience.
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In the case of Derek Jeter and 3, 000 hits, fans are completely enamored with the notion that Jeter is the only Yankee to have achieved this historic accomplishment.
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Many have suggested that the only solution for publishers is to re-imagine themselves as Hollywood studios and go fishing for blockbuster hits such as the next Harry Potter or Twilight series.
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Now rather than find another way to fill up all that pesky prime time air not occupied by Heroes, Reilly need only add to an already established slew of hits come springtime--a task made even easier with the No. 1 show, American Idol, as his launching pad.
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Most of its recent hits, like Iron Man 2 and How to Train Your Dragon, are films that the studio only distributes, meaning it only gets about 12% of the revenue.
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