Just 11 minutes later, a second quake, measuring 6.3, struck 30 miles northeast of Tabriz.
"The quake has created huge panic among the people, " one resident of Tabriz told the BBC.
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The quakes struck near Tabriz and Ahar, but most of the casualties are thought to be in outlying villages.
The original manuscript is kept sealed in the Manuscripts Section of the Central Library in Tabriz, the Islamic Republic of Iran.
Tabriz under the Ilkhanids became a centre of book production and manuscript illustration and this important document was treated with appropriate care.
Scores of villages were destroyed or damaged by the quakes, which struck East Azarbaijan province northeast of Tabriz, the country's fourth-largest city.
CNN: More than 300 killed, 3,000 injured in Iran earthquakes
Serious clashes broke out between students and the conservative-dominated security forces in Tehran and Tabriz in July 1999, triggered by the closing of a leading pro-reformist newspaper, Salam.
The first earthquake, with a magnitude of 6.4, hit Saturday at 4:53 p.m. local time, 37 miles northeast of Tabriz, according to the U.S. Geological Survey, which measured 11 aftershocks.
The quakes struck near Tabriz, the country's fourth-largest city.
The manuscript is 382 pages long, of which the first 290 pages were written by Rashid al-Din himself, and the rest by the Governor of Tabriz, Abdullah Bin Mohammad Tabrizi and two scribes.
"We feel extremely hurt, as if they are deliberating ignoring us because we are an ethnic minority, or maybe they want to pretend there is no crisis in this country, " said Navid, a businessman in Tabriz.
The manuscript was kept in the private house of the Serajmir family in Tabriz until 1969, when the Iranian National Heritage Society bought it and the Society of National Honors, Iran, recognized and registered this manuscript as national heritage in 1975.
In Tabriz and nearby Ardabil, the two major cities near the earthquake area, several local businesses, teachers and college professors had created ad hoc relief teams, separate from the government, and were sending truckloads of food, water and blankets to the area.
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