In women with specificriskfactors, a clinician should weigh up the advantages and disadvantages of alternative therapies compared to those of traditional HRT.
First, the AHA guidelines were designed based on knowledge of riskfactors for cardiovascular disease and thus did not take into account certain riskfactors for specific cancers.
And the other big things such as global systemic risk and hegemon country risk (more on that later), and those non-company specificfactors generally dwarf the risk due to company choice in a well diversified portfolio.
Epidemiology has a long list of accomplishments, including most famously identification of the association of smoking with risk of lung cancer, but also encompassing the identification of many other exposures, medications, and infectious agents as riskfactors or protective factors for specific diseases.