Liverpool had gone close several times before Simao Sabrosa opened the scoring for Benfica.
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Liverpool were then thankful to keeper Reina when his fingertips diverted Simao's shot on to an upright.
Previously, Liverpool had been warned when Sabrosa Simao volleyed over from 10 yards from Pernia's low cross.
Portugese striker Helder Postiga came in for Dame N'Doye while set-piece specialist Aendreas Ivanschitz replaced Simao in midfield.
Simao says this is a difficult time in the fight against the pandemic because many people have grown complacent.
Mariangela Simao, the director of Brazil's AIDS program, was in the crowd.
First to threaten was Miguel Simao who took on Hibs defender Mathias Jack and easily beat him for pace down the right-hand wing.
The RM 008 chronograph tourbillon (a stopwatch) was so complicated that only one master watchmaker, Fernand Simao, had the skills to put it together.
Benfica's confidence was growing, and Van der Sar was in action again as he dived to his left to save from the dangerous Simao.
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Jamie Carragher misjudged a long ball to let Forlan in, and he found Simao, who drove a top-class finish across Reina into the bottom corner.
Mozambican Foreign Minister Leonardo Simao warned that the rain of the past 48 hours could cause rivers to burst again and re-flood areas just beginning to dry out.
Almeida somehow missed the target after rising to meet Simao's inviting deep cross, while Tiago wasted another good opening when he nodded wide from Fabio Coentrao's driven centre.
But Giggs had better luck when United took the lead seven minutes before the interval, his free-kick inadvertently glancing off Simao past the stranded Moreira after Cristiano Ronaldo had been fouled.
BBC: SPORT | Football | Europe | Manchester United 2-1 Benfica
Atletico had another good chance just before the hour but a great save from Reina denied Simao, whose thunderous volley from an Ujfalusi cross looked on its way into the top corner.
"We learn to exchange e-mail, make our own Web pages and, best of all, improve our English, " says Yang Yimei, who is from the town of Simao, in China's southwestern Yunnan province.
Cech then denied Simao Sabrosa, and at the other end Tomas Ujfalusi's header flashed past the past from another corner with Sionko and Milan Baros both just failing to make a vital connection.
Simao made Jens Lehmann work for the first time when he found himself well placed on the right-hand side of the area following good build-up play from Pepe and Deco, but the former Arsenal stopper was equal to the Atletico Madrid winger's effort.
The Spanish side decided to test their visitors from the whistle and it quickly became apparent that the Liverpool back four were not sure how to deal with ex-Arsenal man Jose Antonio Reyes and Simao operating down the wings, with Jose Manuel Jurado playing just behind Forlan.
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