Letting radicals air their views can have a serious effect on how people view your faith.
Nor is it likely that the tiny quantities used in house-spraying have any serious effect on the environment.
That may not sound much, but it would have a serious effect on a country's brainpower if it were widespread.
Hopefully, the election being over will also end the perceived need for both sides to tear each other apart, to so severely divide the country, which has had such a serious effect on consumer and business confidence.
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Those will take years, and a single serious side effect could sink the drug.
Doubts grew that Avastin wouldn't work, or that some serious side effect such as gastrointestinal bleeding would ground the once-promising drug.
In long-term use it carries a one in 30, 000 risk of a serious side effect - the bone marrow disorder aplastic anaemia.
Its most serious known effect is liver cancer about 10-15 years after exposure, so it is not exactly a shock anti-personnel weapon.
Elan and American Home Products have ended trials of their Alzheimer's vaccine--once seen as one of the most promising new approaches to treating the disease--after 15 patients suffered a potentially serious side effect: swelling of the central nervous system.
But a serious new side effect was discovered that might torpedo the drug.
More serious is the effect of Telkom, the state telephone monopoly.
The blast on Saturday morning was the first serious incident since the ceasefire took effect on Tuesday.
Translation: big tax increases or spending cuts right now would be a bad idea given the fragile state of the economy, but committing to serious debt reduction that will take effect once the economy has recovered is urgent if we are to avoid a budget catastrophe.
But eventually her words had the intended effect, because I got serious about my studies.
The effect on Slovak industry is serious, because companies can no longer raise equity finance.
Goldman Sachs just warned yesterday about this ripple effect, which can be very serious.
Mercedes has transferred much of the hefty, serious switchgear from the SLS into the SL to good effect.
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In fact, the lack of a single market in money is a serious blockage in the economy that can have a direct effect on companies.
Second, the Smithian effect mitigates rising inequality in India, a serious issue: 48 billionaires in India own 10.9 percent of the GDP (in China, another country with significant inequality, 95 billionaires represent only 2.6 percent of GDP).
In court, O'Connor's demeanor is serious and studied, her questions spare and pointed on the practical effect of laws.
However, right now, government policies (Obamacare above all) are having the effect of reducing, rather than increasing, investment in serious medicine.
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There are already about 3, 000 serious prospective buyers, according to Sheriff, though no waiting list is in effect yet.
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Most of the really serious cuts phase in between 2005 and 2010, but substantial changes go into effect next year.
"It is serious, but we are part of the public sector and everyone is feeling the effect of cuts, " he said.
It shares the concerns eloquently expressed last week by House Banking Committee Chairman Henry Gonzalez (D-TX) to the effect that absent such transparency and discipline, we will wind up repeating serious mistakes made with taxpayer resources in past aid to both Baghdad and Moscow.
But if the toxic effects were caused directly by the intended effect of the drug (blocking gamma secretase), that would raise serious questions as to whether it is safe to continue with other trials of gamma secretase drugs now ongoing at other drug companies including Bristol-Myers Squibb.
That would be South Korea, where gaming addiction is a serious problem among youths, so much so that last year a ban went into effect which does not allow kids under the age of 16 to game online between 12 AM and 6 AM in order to force them to get some sleep.
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The fighting, which eased at nightfall, was by far the most serious violation of a cease-fire brokered by NATO and the European Union that took effect July 5.
Two landmark studies last year in the New England Journal of Medicine found that a similar spine procedure (vertebroplasty) was no better than a fake operation--raising serious questions over whether the pain relief patients report from kyphoplasty is nothing more than an expensive placebo effect.
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