Winger Sackey acknowledged England's most promising moves were down to Wilkinson's influence in midfield.
Wasps scored through Paul Sackey, with Dave Walder converting, to make it 8-7 seconds before half-time.
Matt Stevens, Nick Easter, Martin Corry and Paul Sackey come in, with Jason Robinson moving to full-back.
Wasps maintained their dominance after the break and tries from Paul Sackey and Josh Lewsey sealed victory.
It is a tough draw for the Black Queens which is why Sackey is concerned about their build-up.
Shaun Edwards, Gatland's new defensive assistant, said the denying England a second try, through Paul Sackey, was crucial.
The Exiles feature England Sevens players Paul Sackey and Geoff Appleford, while Quins include exciting wing Ugo Monye.
Some intense pressure and incisive passing ended with Sackey going over on the right, Cipriani adding the extras.
Danny Cipriani kicked 18 points on his first start while Paul Sackey, Mathew Tait and Jamie Noon all crossed.
"Everyone says it's a blessing (for Wasps players) that he's the coach, but it's not, " Sackey told BBC Sport.
The gifted number 10 converted all three scores and set up Sackey for the fourth try with an inch-perfect cross-kick.
The visitors took a 12-10 lead into the break, but Wasps went well clear with Paul Sackey and Danny Cipriani tries.
Because of this Sackey is not rating her team's chances too highly.
Sackey is one of a number of Test stars at Wasps harbouring strong hopes of selection for the tour to South Africa.
The home side though, made sure of the bonus point when Sackey crossed in the corner with 13 minutes left to play.
Cipriani's Wasps team-mate Paul Sackey has also been included by the Baa-Baas.
Facing Toulon pitches Thorpe against former Exile Paul Sackey, who was a senior player at Irish when Thorpe was in the club's academy.
Wilkinson landed three penalties and two conversions and set up England's opening try with a cute break and offload to winger Paul Sackey.
Paul Sackey was bravery personified in his personal duel with Tuilagi, never giving his formidable opponent room in which to utilise his power.
Inside Sackey and Voyce, centres Fraser Waters and Josh Lewsey and fly-half Alex King were equally belligerent, squeezing the life out of Leicester.
And with fellow wingers Paul Sackey injured and Ugo Monye on Lions duty he staked his claim with a performance that impressed Johnson.
First he cross-kicked a penalty unsuccessfully to Paul Sackey with three points on offer, before handing Bath the decisive try on a plate.
Wasps made a real statement of intent at the start of the second half, with Sackey scoring one of the tries of the season.
Tries from Paul Sackey and Richard Wigglesworth, along with 14 points from Jonny Wilkinson, helped England to a 24-13 win over a youthful French side.
Francisco Leonelli scored twice for the hosts but Raphael Ibanez, Tom Voyce, Dominic Waldouck (2) and Paul Sackey tries gave Wasps a 35-12 interval lead.
He slipped a neat inside pass for Sackey to score under the posts and Walder's conversion brought Wasps back to within a point at half-time.
Cipriani made the score 15-0 after just 18 minutes with a penalty before delivering a superb inside pass to Sackey for a sparkling third try.
Stevens replaces Vickery, Easter comes in for Dallaglio at number eight, while Corry steps in for Worsley at flanker and Sackey starts on the left wing.
But can the selectors ignore the likes of Mark Jones, Paul Sackey, Mark Cueto, Thom Evans and Josh Lewsey, who can also play full-back and centre?
The home side dominated the first half and led by the inspired Danny Cipriani, went 22-0 ahead with tries from Eoin Reddan, Tom Voyce and Paul Sackey.
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