But half-back Richard Horne is expected to return earlier than expected after a foot injury.
Leuluai then denied Richard Horne with a crunching last-ditch tackle and Yeaman then went without the ball after Paul Cooke had fashioned a half-chance.
Cooke is Hull FC's joint longest-serving player, alongside Richard Horne, and has amassed 798 points from 221 appearances in his nine seasons with the club.
The visitors were barely on the pitch before first Will Robinson sliced through for a try then teenage half-back Richard Horne produced a blistering solo effort.
Centre Keith Senior crossed for Leeds, but Hull edged further ahead before the break as Domic, benefiting from Richard Horne's clever pass, and Whiting both added tries.
Tries from Gareth Moore and Kyle Amor gave the hosts an early lead before Joe Westerman, Kirk Yeaman and Richard Horne put Hull in front at half-time.
Hull centre Yeaman also reached a significant landmark in the first half when he scored his 100th try for Hull following a brilliant one-handed gather from Richard Horne's grubber kick.
Steve Collins romped in within 60 seconds of the re-start after a brilliant break by his skipper Tony Grimaldi and then teenage half-back Richard Horne showed his dazzling footwork for another try.
Danny Tickle, who had converted both scores, kicked a penalty soon after the break before playing a part in a fine move also involving Jordan Tansey and Richard Horne which ended with Long crashing over.
As the game progressed, Hull appeared more fatigued, and when Richard Horne's laboured pass went loose Daryl Millard pounced and stepped twice before fending off Tansey to score a great try - again converted by Cooke.
Inept handling hampered the home side's efforts before the break but teenage stand-off Richard Horne sparked the fightback just two minutes into the second half when he skipped past veteran Daryl Powell for his side's first try.
It got worse for Wigan on 31 minutes when Richard Horne somehow managed to get over for his 100th career try, despite the efforts of four Wigan defenders who failed to stop him getting the ball over the line.
The Black and Whites had beaten Rovers three times this season, first in Richard Horne's testimonial in January before getting the better of two tight Super League encounters, an 18-14 win at Craven Park on Good Friday followed by a 20-16 victory at the KC Stadium in July.
As Harlequins began to close the game out, Jamie Thackray was held up over the try-line, before Matt Gafa collected Horne's kick in goal despite intense pressure from the onrushing Richard Whiting to seal the win.
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