Real Betis have completed the signing of French born Poland international Damien Perquis from Sochaux.
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Guardiola's team still hold a 29-point lead over third-placed Valencia, who host Real Betis on Sunday.
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Barcelona can win what would be its 22nd league title in the next round against Real Betis.
Real Sociedad drew 1-1 at home to Real Betis, a result which left both teams comfortably clear of the relegation zone.
In Thursday's other games, Real Betis made it through to the last eight with a 2-1 aggregate win over Las Palmas.
Sixth-placed Malaga drew 0-0 with Sevilla, while seventh-placed Real Betis won 1-0 at home to second-bottom Celta Vigo, with Ruben Castro scoring the second-half winner.
Earlier on Saturday in Spain Real Betis defender Miki Roque, a former Liverpool youth player, announced he needs surgery on a malignant tumour in his pelvis.
Granada suffered a 2-1 home defeat by Mallorca, Espanyol drew 0-0 with Valladolid and Real Sociedad shared a six-goal thriller with Real Betis as it ended 3-3.
There was just one game in Spain where Atletico Madrid went second in La Liga, and six points clear of city rivals Real, after winning 4-2 at Real Betis.
Real Sociedad claimed fourth place with a 4-1 win at home to Valladolid, while Valencia moved up to seventh with a 3-0 victory over fellow European hopefuls Real Betis.
The victory meant Real finished nine points ahead of archrivals Barcelona in second, who said farewell to departing coach Pep Guardiola with a 2-2 draw at Real Betis Saturday.
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Negredo netted his second from the spot before Manu del Moral completed the rout to set up a last-four clash with either Atletico Madrid or fierce rival Real Betis.
Earlier, Junior Paulao scored as Real Betis moved up to third with a 1-0 win over Espanyol, who had midfielder Wakaso Mubarak sent off for a second yellow card in the second half.
Barcelona saw their lead at the top of the Spanish league cut to seven points at the weekend when they lost 2-1 to city rivals Espanyol and Real Madrid thrashed Real Betis 6-1.
The following week Betis beats Real Madrid 1-0 and Sevilla loses 4-0 to Atletico Madrid.
Fourth-placed Malaga spurned the chance to close the gap on Real after drawing 1-1 with Real Zaragoza, but Betis stayed a point behind in fifth after Diego Costa's 61st-minute winner for Atletico.
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