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This is just one example of the profound differences between the sexes to drugs.
BBC: NEWS | Health | The dawn of gender-specific drugs
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"There are really quite profound differences as a function of how we live our lives, " she says.
BBC: City living 'makes it harder to concentrate'
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This, they believe, indicates profound differences in the way the disease was caused.
BBC: MS 'may be four different diseases'
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There were differences, very profound differences, and yet there was still a sense I think that the differences between the parties could be bridged.
WHITEHOUSE: Remarks by the President at a Campaign Event
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And so this notion that somehow two different countries are going to have identical economic programs doesn't take into account profound differences in position.
WHITEHOUSE: President Obama and Prime Minister Cameron Hold a Press Conference | The White House
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He also noted that "people have to be aware of very profound differences in copyright law, so you can't just transpose this project to other countries".
BBC: Turning the page on Google books
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It is another to tear down distinctions between democratic and despotic governments, ignoring profound differences of principle in the hope that appeasing and engaging, with maybe some cash thrown in, will bring peace.
CENTERFORSECURITYPOLICY: Obama, the appeaser?
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It would be surprising if there were not profound differences over one of the biggest issues China faces: how to adapt the political system, organised along Leninist lines and designed for a monolithic command economy, to suit modern China, with a booming private sector and fast-growing middle class.
ECONOMIST: Banyan
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The small differences in price in this narrow range are far more profound than bigger jumps higher up the cost spectrum.
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