Premier League midfield duo Steven Pienaar of Everton and Fulham's Kagiso Dikgacoi were both selected.
Ulster-bound Ruan Pienaar of the Sharks partners Januarie, now back with the Stormers, at half-back.
Ruan Pienaar and Francois Steyn targeted the rookie Osprey, peppering him with kicks in behind.
Frans Steyn and Ruan Pienaar kicked penalties before the latter went over for the first try.
Pienaar, having missed two conversions, gave way to Humphreys who slotted an excellent touchline conversion.
Everton went close through a curling effort from Steven Pienaar, while Rui Patricio saved from Louis Saha.
Ulster attacked from the start and were 3-0 up in the second minute through a Pienaar penalty.
John Carew slammed in to reduce the arrears, but Pienaar restored the two-goal advantage with a great 20-yarder.
Meanwhile, Everton's Steven Pienaar has joined up with his South African team-mates at their World Cup training camp.
"The Eastleigh campaign is by far the biggest campaign UKIP has ever fought, " he told BBC 5Live's Pienaar's Politics.
But they responded well and Steven Pienaar converted Leon Osman's cross with a fine strike to open the scoring.
Osman broke free on the right and raced towards the byline before picking out Pienaar with an inch-perfect centre.
Scrum-half Ruan Pienaar and centre Wynand Olivier are the only other changes to the squad from the Samoa game.
The province were just 11-6 up at the interval thanks to Andrew Trimble's try and two Ruan Pienaar penalties.
Marouane Fellaini headed over in a poor first half before Steven Pienaar's shot was well saved as Everton pressed.
Steven Pienaar also came close for the hosts when his 25-yard shot was palmed wide by keeper Julio Cesar.
Marouane Fellaini headed home the opener in the 42nd minute before Steven Pienaar doubled the lead in the 59th minute.
Robbie Diack picked up and fed Pienaar, whose superb flick pass found Trimble and he charged over in the corner.
Marouane Fellaini gave Everton the lead when he slotted in Leighton Baines' cross before Tim Cahill headed in Steven Pienaar's corner.
Pienaar inexplicably missed the conversion but his embarrassment was countered by Hougaard, who made a complete hash of a long-range penalty.
Pienaar said the professional attitude of Ajax Cape Town, a subsidiary of Ajax Amsterdam, made his transition to European football easier.
Despite picking up three points at Ewood Park, Spurs suffered the last-minute loss of key midfielders Steven Pienaar and Luka Modric.
Ruan Pienaar has also been switched from his usual scrum-half role to fly-half for the first time, partnering Fourie de Preez.
The defender received his first yellow for over-celebrating his goal and moments later was booked for a challenge on Steven Pienaar.
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The Australian's brilliantly inventive backheel was straight into the path of Pienaar, who slid and scooped the ball into the top corner.
Pienaar is battling a groin injury which forced him to miss Tottenham Hostpur's goalless draw at home to West Ham on Saturday.
Liverpool remains seventh in the standings five points and a place below neighbor Everton, which beat Fulham 1-0 on Steve Pienaar's goal.
Steven Pienaar marked his 100th game for the club with a fine left-footed finish after a clever backheel from the inspirational Tim Cahill.
Everton's Steven Pienaar hit the bar soon after while from Mikel Arteta's smart free-kick Jack Rodwell glanced a second-half header just inches wide.
Last weekend's match-winner Morne Steyn starts in place of fly-half in place of Ruan Pienaar, who has paid for his poor goalkicking form.
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