Today Norton's "dose-dense" regimen is common practice for certain breast cancer patients at high risk of relapse after surgery.
Mr. Swartz was referred to Mehdi Shishehbor, a cardiologist at Cleveland Clinic, who specializes in PAD patients at high risk for amputation.
Moreover, he says, the trial excluded patients at high risk for bleeding, such as those with central nervous system tumors or vascular problems.
By excluding patients at high risk of bleeding, the number of bleeding deaths was cut to a little more than 1% of those taking Avastin.
In a bold move, Pfizer is testing Celebrex in patients at high risk for heart attacks--and it says it expects the drug may actually reduce cardiovascular disease.
Gail Cawkwell , a medical director at Pfizer, said that the drug giant would not be conducting a trial in patients with acute coronary syndrome, but instead in patients at high risk for heart attacks.
Robert Flores, the group's medical director of population health management, says primary care physicians use the team to help them manage patients at high risk of hospitalization or re-hospitalization who can't easily get to a doctor's office.
Lilly and Sankyo have high hopes for the drug, and are testing in a big trial to prove that prasugrel is better that Plavix in preventing heart attacks, strokes and other cardiovascular events in patients at high risk.
Health plans are also using claims data to identify patients at high risk for rehospitalization and helping coordinate care at home "so patients don't slide back, " says Karen Ignagni, chief executive of America's Health Insurance Plans, an industry association.
In short, bariatric surgery involves so many risks that it should be used only as a last resort after diet and exercise have failed and then only with patients at high risk of mortality (from heart disease or diabetes, for example) because of their weight.
Such patients are at high risk of death due to obesity-related illnesses, such as heart disease and type 2 diabetes.
CNN: Weight-loss surgery safe, but sleep apnea increases risk
Heart failure patients are at high risk for kidney problems anyway, and any safety issue could be lost in the noise.
Last year, the Journal of the American Medical Association published a review of models that predict which patients are at high risk for hospital readmission.
In an interview, FDA psychiatry drugs unit director Thomas Laughren says he supports more studies in patients at high-risk of suicide, and has given speeches to that effect.
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After years of controversy, the Food and Drug Administration has asked Abbott Laboratories to yank the weight loss drug Meridia, generically known as sibutramine, from the market as a result of a large clinical trial that found the drug increased the rate of heart attack and stroke in patients at high cardiovascular risk.
Screens differ from diagnostic tests in that screens are aimed at patients who are not at unusually high risk and exhibit no particularly alarming symptoms.
He maintains that the right Cox-2 pill could be a boon to patients who are at high risk for stomach bleeding and low risk for heart attacks.
According to Dr. Sana Al-Khatib, lead researcher of the study published Tuesday in the Journal of the American Medical Association, ICDs often are recommended as a primary prevention tactic for patients who are at high risk for a cardiac arrest or life-threatening arrhythmia, but who have not yet suffered from these symptoms.
This study enrolled 25, 673 patients considered to be at high risk for CV events.
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Up to 13% of patients were found to be at high risk of coronary heart disease using traditional assessment tools.
However, overall 10% fewer patients were rated as being at high risk.
AdhereTx: Supports team-based medication management and reconciliation for high-risk patients at the point of care.
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From the start, the COX-2 drugs were designed for a limited number of patients--those who were at high risk for ulcers and other stomach problems.
Mark Turco, chief medical officer of Covidien's vascular business, said there are patients who would be "at very high risk" for stroke, "and the physician may feel uncomfortable" just giving drugs.
In another National Cancer Institute study of 2, 000 people at high risk for colon cancer, patients who took very high doses of Celebrex for three years had more than triple the risk of serious heart problems compared with those who got a placebo.
Nissen says that to properly examine the cardiovascular risk issue, researchers need to specifically study arthritis patients who already have coronary heart disease, or are at a very high risk of getting it soon.
After patients filled out enhanced questionnaires that sought more complete information, the percentage considered at high risk jumped to 18%.
The Royal National Institute for the Blind, a member of the alliance, said patients awaiting treatment at the Royal Liverpool University Hospital, for instance, were at high risk of losing their sight.
At the University of Utah, nurse Stephanie Wallace links high-risk patients to the outside care that could keep them from returning.
He said there was also a risk that the new beds would be used to treat emergency patients at times of high demand.
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