The ill-fated diet drug fenfluramine, for example, stimulated dopamine release within the hypothalamus and had the paradoxicaleffect of reducing appetite.
This approach has the paradoxicaleffect of heightening the tragedy, so much so that the audience actually gasps when Romeo stabs Tybalt (Charlie Francis Murphy).
It's the controversial thesis of University of Massachusetts toxicologist and school of public health professor Edward Calabrese that small doses of certain poisons may have the paradoxicaleffect of lengthening life spans.