Rising highest to meet Danny Williams' free-kick, Wright could only direct his header across and wide of goal from six yards.
Wales were still showing their teeth on the counter and Joe Ledley was unfortunate he could only direct a header at Akinfeev after good work from Ricketts.
Eren Derdiyok came close to equalising in the first half but could only direct his header from Tranquillo Barnetta's left-wing cross straight at Hertha goalkeeper Jaroslav Drobny.
Datolo leveled in the 64th minute when he pounced after keeper Gianluigi Buffon could only parry a header from German Denis and the rebound fell in his path.
Edgar Alvarez hooked over a cross for David Suazo, who could only plant his header wide, and then Alvarez himself drew a superb one-handed save from Swiss goalkeeper Diego Benaglio.
Blackpool were almost level in the blink of an eye as Phillips sprung Birmingham's offside trap to meet Adam's whipped free-kick but he could only glance his header wastefully wide.
Toffees centre-back Sylvain Distin could only loop a clearing header back towards his own goal to let in Cameron Jerome but the Blues striker controlled on his thigh only to half-volley wide from just inside the area.
Santa Cruz was picked out by a Stephen Warnock cross, only to plant his header straight at Korhnonen.
Osman then missed Everton's best chance when he failed to control Yakubu's header with only James between him and the opening goal.
Gary Cahill met a Mark Davies corner with a firm header and only a goal-line clearance from Fagan prevented Hull going further behind.
From a corner soon afterwards, Luisao climed above his marker Yakubu with a well-timed leap, only to put his header over the bar.
Roma briefly raised their game and Philippe Mexes should have levelled, only to steer a header wide from an invitingly whipped in Cicinho cross.
The best chance of the half fell to Anelka, who reacted quickest to a left-wing cross from Franck Ribery but could only loop a weak header over the crossbar.
The surge in West Ham's confidence was instant, with Wigan keeper Ali Al-Habsi saving twice in swift succession from Stanislas' rising effort and Piquionne's header from only six yards out.
Semih justified his second-half introduction when he rose highest to meet Nihat's superb inswinging cross from the left flank, and Benaglio could only palm the powerful header into the back of the net.
Occasionally the visitors managed to break out of their own half but they failed to cause any real problems, with a weak shot from impressive Alex Meechan and a Jamie Impey header the only moments of note.
Fulham had less of the ball than Everton boss David Moyes's team and it took well over half an hour before Zoltan Gera produced their first shot, when Dickson Etuhu marauded into the box only to place his header straight at Howard.
Liverpool were denied what appeared to be a legitimate goal when a Kyrgiakos header was only parried against Cole by Kivrak and, despite Poulsen forcing the loose ball in, the goal was disallowed for a foul on the visiting keeper as Trabzonspor held on to keep themselves firmly in the tie.
The former Manchester United winger then set up Robbie Blake for a header that was only inches off target in the 23rd minute.
Anelka ghosted on to Stelios' cross only to place a deft header straight at Robinson but, despite being a man light, Spurs still posed Bolton problems.
Everton's only serious response was a header from midfield man Jack Rodwell that flew just wide and Moyes made an alteration the situation demanded at the interval, removing defender Tony Hibbert in favour of striker Jermaine Beckford.
Bowyer ran on to Cameron Jerome's cushioned header to fire the only goal past keeper Petr Cech after 17 minutes.
Van Persie whipped in a free-kick from the right and Gallas rose to glance in a header that Gomes could only touch on its way in.
Dagenham took the lead inside four minutes as Roche could only palm Josh Scott's header into the path of Benson, who tapped home his 19th goal of the season.
Stefan Klos kept Rangers in front when Martyn Corrigan met Steven Hammell's free kick with a header from six yards only for the German to block the effort with his chest.
Kyle Walker's long-range strike put the hosts back in front only for Clint Dempsey's late header to give the visitors a share of the spoils.
And the cost of that miss was emphasised right after half-time as Sturridge hammered home from close range when Lonergan could only block John Terry's free header.
Roman Hubnik scored the only goal with a close-range header in the 70th minute, but it was a game that rarely featured Scotland as an attacking force.
Watford were understandably demoralised, but Henderson almost got his second of the night after 81 minutes, only for Bryan Hughes to clear his header off the line.
Wigan's stopper was eventually beaten and he stood motionless as he watched a Cahill header fly past him, only for the post to come to his rescue.
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