One challenge ahead is for ad agencies to learn how mobile location-based messaging works best.
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Speaking of activity, that is one challenge for sporting goods stores the lack of activity.
One challenge with embryonic stem cells, however, is preventing them from creating tumor cells.
One challenge holding back venture-backed companies outside the U.S., said Breyer, was the ability to scale.
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One challenge in understanding network effects is to spot the differences between several sorts of network.
However, one challenge will be how to involve a major voice in what drives youth sports: Parents.
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One challenge is the lack of consensus on what core indicators to use to monitor HIV care.
If there was one challenge in the original game that nobody enjoyed it was the frames-per-second in Blighttown.
"One challenge in supercomputers today is power consumption, " said Jeff Nichols, associate laboratory director for computing and computational sciences.
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One challenge will be getting makers of movies and television shows to change how they make their content available.
Crunching the numbers is one challenge, obtaining the numbers to crunch is another.
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"One challenge we face is that we call ourselves group dating, " said Sachs.
One challenge his company faces in meeting this demand is finding quality clinicians.
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One challenge was making sure that the network capacity could handle the demands of the many smartphones and tablet users.
One challenge facing OpenGamma is that its software is in the middle area of the spectrum between proprietary software and infrastructure.
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One challenge for Quora will likely come in maintaining its campfire-circle quality as the site grows beyond its current core audience.
The reason for this is not my stylish writing, but that attracting new clients is the number one challenge for entrepreneurs.
One challenge I have faced while going to school has been being the first in my family to go to college.
My artistic friend has noted that the number one challenge of being a wood carver is keeping the carving knives razor sharp.
One challenge, Bronfein admits, is teaching customers how to order very precisely.
His number one challenge now is to keep the auction volume up.
The coroner says one challenge has been fixing a time of death for Katrina's victims, so he says he's made an arbitrary decision.
One challenge for a large IT project is that the county has 20 cities, six towns, and nine villages, each with its own government.
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More than half of firms in the oil and gas sector warn that skill shortages are their number one challenge, a survey has found.
One challenge would involve creating a magnetic head that could hover over those dots, read their signal and write new data onto the grid.
One challenge is to ensure that the application is uniform and without bubbles or dry areas which would result in ensuing weakness of the blade.
One challenge for potential investors is how they will eventually exit.
One challenge is simply finding large new deposits not already mined.
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"It's the number one challenge in a family business, " he says.
Its illicit nuclear program is just one challenge that Iran poses.
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