Newcastle had opportunites to grasp at a lifeline in the first half, with Obafemi Martins firing off target and Mark Viduka having a shot cleared off the line by Carlos Cuellar.
Paul Meegan had an injury-time chance from 30 metres from Monaghan but he pulled his shot off target.
It was United's turn to be knocked out of their stride and Marco Paixao was off target with a pot shot from 25 yards.
Joe Cole, on for the injured Lampard, almost got in the act, but his shot was off target.
He also curled a shot just off target after 49 minutes - before Viduka had Middlesbrough's best chance two minutes later.
Accies came close to extending their lead nine minutes before half-time when Alex Neil's corner struck the post and Mensing's rebound shot swerved off target.
At that stage the score was harsh on Hull, who saw a Sonko header deflected wide and a Geovanni shot fly off target, but from then on it was nothing more than an exercise in damage limitation.
Latching on to a pass from Marouane Chamakh, who appeared to control the ball with his arm in the build-up, Bendtner raced clear and fired off target, only for his shot to get a helpful diversion off the sliding Clarke and into the far corner.
He also saw a deflected shot fly just off target after the break.
Luka Modric, so influential in recent matches under Redknapp had one weaving run but his shot was way off target.
McCarthy had a chance to put Hamilton in front in the opening minutes when he met Lucas Akins' cross with a shot which went off target.
Dean Shiels was off target with a left-footed shot from the left side of the area and Sharp had another effort blocked by Liam Fontaine.
Motherwell had another chance to draw level five minutes into the second half, Hammell's cross finding its way to Ian Russell, but his shot was well off target.
As the half-hour mark approached, Aiden McGeady outstripped the Dons back four to set up McDonald, but the Australian's feeble shot was wildly off-target and posed no significant threat.
The Everton youngster linked up well with Kenny Miller after brilliantly beating two men near the corner flag before setting up the Wolves striker for a shot that was sliced well off target.
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It was a bright opening spell, with Hibs carving out the first opening when Derek Riordan was presented with the chance of a shot, but his effort was comfortably off-target.
Blackpool might have made it 4-0 but Matt Phillips was off-target after being put through by LuaLua and although Lowe shot wide too, Wednesday will return to their League One promotion chase having been outclassed.
And they only had themselves - and their poor finishing - to blame, not least Butterfield who fired an early chance over, curled another effort wide of the post, saw another shot held by Rochdale goalkeeper Josh Lillis and was inches off target with a header.
Of Arsenal's other attempts, William Gallas shot over from 10 yards and Eduardo screwed an effort wildly off target - however, that was still more then Bolton managed in the opening 45 minutes.
Straight away Billy Mehmet had a shot as the second half sparked into life, but his effort was off-target.
Villa had opportunities to kill off the tie - and Milner should have slotted home but missed the target after Payer parried a shot across goal from Young.
Zaza did even better to stop Robinho's first-time shot after good work by Stephen Ireland, while Wright-Phillips was horribly off-target following another sublime Elano through-ball.
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