Many are too small to affect the market, and the biggest ones now are in bonds and currencies, whose prices are harder to influence than individual stocks.

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The high cost of technology and the gains it promises are now tipping the balance more firmly in the direction of the very big ones and against small regional or community banks.

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The unlikely duo now have 140 newspapers, mostly small ones, across the U.S. The latest is in Long Beach, Calif.

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Now the company is focusing on testing whether can improve side effects and usefulness in small molecule drugs, including ones for several old chemotherapy medicines.

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