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Current studies show that typical injections of 15mg mtx, plateau off, but with subcutaneous injection, the efficacy increases.
FORBES: Xeljanz, A Cheaper-But-Expensive $25,000-A-Year Pfizer Pill For Rheumatoid Arthritis, Gets FDA Green Light
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If you look at the pharmocokinetic studies, the bioavailability of Subcutaneous MTX gives u almost a dose response linear increase in systemic availability.
FORBES: Xeljanz, A Cheaper-But-Expensive $25,000-A-Year Pfizer Pill For Rheumatoid Arthritis, Gets FDA Green Light
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My post is meant as an fyi and to provide a little information on a potential (future) option regarding the first line treatment of RA using Methotrexate (MTX).
FORBES: Xeljanz, A Cheaper-But-Expensive $25,000-A-Year Pfizer Pill For Rheumatoid Arthritis, Gets FDA Green Light