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Rather than killing cancer cells, these drugs remove the aberrant methylation, reactivating genes which had been silenced.
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Methylation, for instance, can turn off an entire gene instantly, which makes for much more radical change.
ECONOMIST: Genes are not all there is to heredity
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Dr Tung and Dr Gilad found that methylation patterns were systematically different in high- and low-ranking animals.
ECONOMIST: Social status and health
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Epigenesis is yet another way of regulating transcription (the methylation stops this happening).
ECONOMIST: Genomics has not yet delivered the drugs, but it will
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Shirley Tilghman and her colleagues correlated this abnormal growth with disruptions of the methylation patterns on the hybrid offspring's genes.
ECONOMIST: Genes are not all there is to heredity
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This methylation pattern played as great a role in determining a mouse's coat colour as did the underlying gene sequence.
ECONOMIST: Genes are not all there is to heredity
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When mice of the younger generations were crossed with those of a separate and unrelated strain, the methylation and the silencing disappeared in their offspring.
ECONOMIST: Genes are not all there is to heredity
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Methylation, the addition to a base of a group of three hydrogens and a carbon atom, is one way in which genes are regulated.
ECONOMIST: Nanopores may lead the way to a new generation of sequencing
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The German company has been working on an EU-funded pilot, identifying 100, 000 methylation sites on a segment of the DNA bundle known as chromosome six.
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The ability to track methylation is thus scientifically important.
ECONOMIST: Nanopores may lead the way to a new generation of sequencing
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It seems to be important in some sorts of cancer, and there is also evidence that regulation by methylation can be passed from parent to offspring, meaning that characteristics acquired by one generation may be inherited by the next.
ECONOMIST: Nanopores may lead the way to a new generation of sequencing