Vaughan scored 56 before being bowled by Dimitri Mascarenhas in Yorkshire's Division One match against Hampshire.
Jamie How hit three boundaries in making 31 off 25 balls, but was bowled by Mascarenhas (2-25).
Mascarenhas then picked up the wickets of Horton and Flintoff before Tremlett ripped through the Lancashire middle order.
Mascarenhas came to the crease after Shah was trapped lbw by Ryder and struck 31 off 14 balls.
Graeme Swann and Dimitri Mascarenhas came into a team featuring 10 players who had bowled in international cricket before.
Hampshire skipper Dimitri Mascarenhas removed Law in the next over as he had him caught behind by Nic Pothas.
"Hampshire chose to release Dimitri Mascarenhas, it was entirely their decision, " said Clarke.
First-innings hero Mark Davies gave Durham renewed hope when he bowled Mascarenhas off his pads with 31 still needed.
Mascarenhas was in particularly good fettle, hitting eight fours and two sixes to reach 75 not out at the close.
For example, Hampshire captain Dimitri Mascarenhas would have to play for Rajasthan Royals in the world event if both sides qualify.
The 21-year-old drove loosely at an outswinger from Dimitri Mascarenhas and edged to Nic Pothas behind the stumps for a duck.
The 19th over, bowled by Afridi, featured a pulled four by Mascarenhas and a terrific back-foot six over long-off from Foster.
Dimitri Mascarenhas (26) was dropped on 11, while Ervine hit 14 fours in 169 balls as the 240 target was achieved.
The big surprise came when Bopara, who was bowled by Jadeja for 37, was replaced by Dimitri Mascarenhas, rather than Owais Shah.
Kevin Pietersen struck 43 off 23 balls while Dimitri Mascarenhas, who later took 2-19, struck four consecutive sixes as England posted 184-8.
The ECB may have sanctioned Mascarenhas's Indian adventure but it seems a line in the sand has been drawn for centrally-contracted players.
Mascarenhas hit 18 fours but was denied his first ton for two years when on 99 he was Jon Batty's 500th dismissal.
Luke Wright had no opportunity at all, so I am not convinced that the return of Dimitri Mascarenhas will have any impact whatsoever.
England should have had a breakthrough when Sehwag sliced Collingwood to fine third man on 39, where Mascarenhas over-ran to miss the chance.
He fell trying to force a good ball from Mascarenhas which kept a bit low as it nipped back to hit off stump.
The home side's captain Dimitri Mascarenhas picked up 6-67 as he earned his best figures for two years by mopping up the tail.
Hants resumed needing another 155 from 17.3 overs, adding 16 before losing remaining frontline batsmen Nic Pothas and Dimi Mascarenhas in seven balls.
Dimitri Mascarenhas was Hampshire's top scorer with 52 from 71 balls, sharing in a stand of 47 for the second wicket with John Stephenson.
It was the second wicket to fall in the seventh over after Pietersen had caught How in the deep off the bowling of Mascarenhas.
Dimitri Mascarenhas became the first England player to be signed by the Indian Premier League when he was recruited by Jaipur in March 2008.
Mascarenhas captured his first one-day international wicket with the key scalp of Dravid, who swept and was expertly taken by Prior at the stumps.
Though the IPL was a success in its first season, only one English player - Hampshire's Dimitri Mascarenhas - played any part in it.
After their trip to Ireland was washed out, Dimitri Mascarenhas' side bounced back from their second defeat by Worcestershire with wins against Nottinghamshire and Ireland.
So far, Hampshire all-rounder Dimitri Mascarenhas, who has played one-day and Twenty20 cricket for England, is the only Englishman to sign up for the league.
Dimitri Mascarenhas and Greg Lamb both made it to the 20s before losing their wickets as Sajid Mahmood and Gary Keedy picked up two apiece.
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