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Is the magnitude of effect, if any, associated with acupuncture for a given clinical indication 'worth it' from the perspective of patients, payers, or policymakers?
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At medical schools, pharma companies, and even at the FDA, biostatisticians and clinical researchers recognize that retrospective data when treated with appropriate bias-controlling statistical methods, can in fact be reliable, particularly as it points to direction of influence and the general magnitude of effect.
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Furthermore, as a recent Institute of Medicine report makes clear, it will be difficult to gauge the magnitude of any effect and the mechanism responsible.
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In the past, the magnitude of this wealth effect has been fairly modest, but it may have grown in many countries over the past decade or so as financial wealth has increased relative to income.
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Retrospective analysis should not be the basis of an FDA approval, of course, but it can and should be the basis to understand direction and general magnitude of an underlying cause-effect relationship, particularly when that relationship is already is well established i.e.
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Even if the sequester goes into effect, the magnitude of the automatic cuts won't be very different from those imposed in 1986.
WSJ: Phil Gramm: Obama and the Sequester Scare
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To support President Obama's case for an increase in the minimum wage, the White House cites a 2009 academic study that says any adverse employment effect from such would be of a small and possibly irrelevant magnitude.
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The cwc's effect, however, will be to mislead Congress and others about the magnitude of the abiding risks in this field.
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The researchers pointed out the findings were consistent with, and of a similar magnitude to, those found for breast cancer although they did not see a cumulative effect.
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