Her group investigated the impact of the vitamin on a chemical in the body, interleukin-17.
The gene forces the body into producing too much of an immune system protein called interleukin-1.
Cytokines like interleukin-1 are not always harmful, but they can interact with chemicals in the brain.
The best treatments up to now, interleukin-2 or interferon-alpha, help only 15% of patients.
He found that in the gut of susceptible mice, dendritic cells have stopped producing interleukin-12.
In 2003 Novartis had been collaborating with Regeneron Pharmaceuticals to test Regeneron's interleukin-1 blocker in rheumatoid arthritis.
Various chemo drugs and interleukin-2 produced nerve damage and other nasty side effects and didn't solve the problem.
Another immune-boosting therapy against cancer, the natural immune system protein interleukin-2, has been limited by severe side effects.
In the 1980s the natural immune protein interleukin-2 was touted as a breakthrough.
All 19 SIDS brains showed strong or moderate levels of interleukin-1 in the same regions of the brain stem.
They are looking at patients who do not respond to steroids as they produce seven times more interleukin-17 than other patients.
Dr Nicoletti said delivering an allergen, such as peanut, alongside the interleukin-12 molecule. may help to bring allergic reactions back under control.
In 2003 British researchers tested Amgen's interleukin-blocking rheumatoid arthritis drug, Kineret, in two Muckle-Wells patients who had not been helped by other drugs.
University researchers had just pinpointed a source: a bad gene that causes the body to produce an oversupply of interleukin-1, an immune system protein.
Novartis' promising Muckle-Wells drug--its antibody against interleukin-1, which it first aimed at arthritis--was one of the first drugs to benefit from Fishman's new testing regimen.
The levels of interleuin-4 and interleukin-1 beta were more than tripled.
The immune system activator interleukin-2 helps 15% of advanced melanoma cases and cures a few, but it produces such devastating side effects that patients must be hospitalized.
In 2003 Novartis had been collaborating with Regeneron Pharmaceuticals (nasdaq: REGN - news - people ) to test Regeneron's interleukin-1 blocker in rheumatoid arthritis.
The immune system cells produce a protein called interleukin-6 (IL-6) that contributes to the overgrowth of lymphatic cells and leads to many of the signs and symptoms of Castleman disease.
This binding process stimulates production of a protein called interleukin-10 (IL-10) that acts as an anti-inflammatory compound and which helps keep the immune system's response to the infection in check.
Six months of treatment with toxic interleukin-2, one of the only treatments for advanced kidney cancer, had eroded nerves in her hands and feet, caused frequent vomiting and made her skin peel all over--but did nothing to slow the tumors' relentless growth.
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