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Basketball players are prone to stress fractures in the tibia, the larger of these two bones, and that can weaken them, he said.
NPR: Louisville's Ware Breaks Leg In Tourney Game
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That, combined with the constant pounding Ware endured through an entire season of basketball, may have created small stress fractures in the tibia and fibula bones in his lower leg, causing his bone to snap when he took a bad step.
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The Boston team investigated whether there was an association between the development of cataracts and lead levels in two bones - the tibia (shin bone) and the patella (kneecap).
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The Arsenal star had surgery after fracturing the fibula and tibia in a challenge with Stoke City's Ryan Shawcross last weekend.
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Former Louisville running back Michael Bush broke his right leg in two places during a football game in 2006 and had surgery the following day to repair his tibia.
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Ramsey underwent surgery to fix fractures to his tibia and fibula in his right leg after the challenge by Shawcross, who was sent off for the challenge and left the field in tears.
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Dr. Reed Estes, assistant professor of orthopedic surgery at the University of Alabama at Birmingham, and team physician for the UAB football team, said Ware's injury "looks like a pretty bad break to both his tibia and fibula, " the two long bones in the lower leg.
NPR: Louisville's Ware Breaks Leg In Tourney Game
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She then suffered a hairline fracture of her tibia just two days before the marathon at the 2000 Olympics in Sydney.
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"You can see in her right knee, especially on the medial side, she has no space left between her femur and her tibia, " he said.
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Kaplan -- who also is not involved in Ware's care -- said it's also possible Ware had a benign bone tumor that weakened the tibia before his fall.
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