Results of the RED-HF (Reduction of Events by Darbepoetin Alfa in Heart Failure) trial were presented at the ACC in San Francisco and published simultaneously in the New England Journal of Medicine.

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But he said that the less-sick outpatient heart failure sufferers in this trial should not be used to draw conclusions about the safety of Natrecor for heart failure inpatients in hospital wards.

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Another new drug, tolvaptan, from Japanese drug firm Otsuka, improved the symptoms of heart failure patients in a clinical trial presented at ACC.

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Separately, Genvec has also been testing skeletal myoblast cell therapy in heart failure patients, recently completing a 28-patient-trial led by Arizona Heart Institute cardiologist Nabil Dib.

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's clinical trial of a gene therapy in patients with advanced heart failure.

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In a giant trial an implanted device sold by Medtronic slashed deaths from heart failure by 25% and reduced hospitalizations by a third.

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Genzyme is itself involved in a European 300-patient phase II trial that attempts to use skeletal muscle cells from the leg to prevent heart failure.

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AtheroGenics saw the failure of its key trial of AGI-1067, a pill designed to prevent heart attacks and strokes, torpedo the chances of the drug being approved in the next year.

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The experts described a very specific clinical trial that would put Natrecor through the ringer, comparing it to the standard of care in heart failure.

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