As expected, mipomersen also resulted in significant reductions in app B, total cholesterol, and non-HDL cholesterol.
The addition of Kynamro helps to reduce low-density lipoprotein-cholesterol (LDL-C), apolipoprotein B, total cholesterol, and non-high density lipoprotein-cholesterol (non HDL-C).
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KYNAMRO, given as a 200 mg weekly subcutaneous injection, has been approved as an adjunct to lipid-lowering medications and diet to reduce low density lipoprotein-cholesterol (LDL-C), apolipoprotein B (Apo B), total cholesterol (TC), and non-high density lipoprotein-cholesterol (non HDL-C) in patients with homozygous familial hypercholesterolemia (HoFH).
FORBES: FDA Approves Mipomersen For Homozygous Familial Hypercholesterolemia
The large doses of fructose from both sucrose (table sugar) and high fructose corn syrup may be particularly detrimental to your health as they can cause the accumulation of metabolically toxic belly fat, cholesterol abnormalities -- including high triglycerides and reduced levels of HDL (good cholesterol) -- and nonalcoholic associated fatty liver disease.
While the shrimp diet did increase people's so-called bad cholesterol or LDL slightly, it also boosted their so-called good cholesterol or HDL enough to offset the increase in bad cholesterol.
In December 2012, the FDA approved Juxtapid (lomitapide) to reduce LDL-C, total cholesterol, apolipoprotein B, and non HDL-C in patients with HoFH.
FORBES: FDA Approves Mipomersen For Homozygous Familial Hypercholesterolemia
It also lowered the so-called good cholesterol, or high-density lipoprotein (HDL), and it did not enter the cell, a characteristic Medford wanted hisdrug to have, because some of the oxidation process takes place within cellular membranes.
Basically, niacin is one of the few compounds known to raise HDL, the so-called good cholesterol, albeit modestly.
FORBES: Will Merck's Failure With Tredaptive Impact How Drugs Are Approved in Europe?
Fifty is the good cholesterol, the HDL -- that should be above 50.
Data to be presented Sunday at a medical conference in Vienna show that Cordaptive cuts bad cholesterol, the stuff that sticks to arteries, by 21% and boosts the artery-cleansing good cholesterol (HDL), according to several Wall Street analysts.
Merck unveiled another kind of HDL-raiser, a drug to inhibit the cholesterol ester transfer protein (CETP).
By using olive oil, you can decrease your total-cholesterol levels while maintaining your HDL levels, thus decreasing your risk for heart disease.
Merck and Roche are also developing other HDL-raising drugs that work by inhibiting the cholesterol-ester transfer protein, similar to a Pfizer drug that failed several years ago.
FORBES: HDL-Raising Drug Fails To Show Benefit In Government Study
Now in human trials, it is the first in a wave of drugs that aim to raise so-called good cholesterol, or HDL, the protein that helps truck chunks of cholesterol away from the arteries.
This created an environment where researchers talked about HDL levels as all-important, ignoring the fact that HDL was much more poorly understood than bad cholesterol.
Both work by inhibiting an obscure molecule called the cholesterol ester transfer protein (CETP) that works indirectly to prevent HDL from being used to create low-density lipoprotein (LDL), the bad cholesterol.
Alcohol, including beer, in moderation raises high-density lipoprotein or HDL, known as good cholesterol, says Dr. R.
The drug is designed to boost high-density lipoprotein (HDL), nicknamed "good cholesterol" because it appears to actually clear plaque from the arteries and reduce the risk of heart attack.
For the company's finances, the most important new drug is torcetrapib, a new medicine designed to raise high-density lipoprotein (HDL), the "good cholesterol, " which is thought to help clear plaque from the arteries.
High-density lipoprotein, better known as HDL or "good cholesterol, " has become a medical mainstay.
In the study where it helped patients lose weight, the drug also raised good cholesterol, or high-density lipoprotein (HDL), by 23%, almost as much as Niaspan, the sustained-release niacin drug made by Kos Pharmaceuticals (nasdaq: KOSP - news - people ) that is the main currently available treatment for raising HDL. Rimonabont also cut triglycerides, another risk factor for heart disease, by 16%.
Apo A-1 is thought to be the key HDL component that removes cholesterol from cells.
FORBES: Early Look: New Methods To Enhance Cholesterol Efflux
Nothing on the market today increases "good cholesterol, " or high-density lipoprotein (HDL), as much as torcetrapib did in early clinical trials.
"The system is set up so that the HDL high density lipoproteins, or artery-cleaning or 'good' cholesterol, cleans out the LDL low density lipoproteins, or 'bad' cholesterol, " she explains.
Researchers speculating about what went wrong thought perhaps torcetrapib made HDL that didn't work, or that HDL itself (short for high-density lipoprotein, and often called "good cholesterol") was less powerful than they thought.
But other companies are filing in behind, including Merck, Roche , Novartis and Kos Pharmaceuticals, the small firm whose niacin preparations are the only marketed drugs to raise 'good cholesterol, ' also known as high-density lipoprotein (HDL).
But other companies are filing in behind, including Merck (nyse: MRK - news - people ), Roche , Novartis (nyse: NVS - news - people ) and Kos Pharmaceuticals (nasdaq: KOSP - news - people ), the small firm whose niacin preparations are the only marketed drugs to raise 'good cholesterol, ' also known as high-density lipoprotein (HDL).
Low-density lipoprotein (LDL) or bad cholesterol levels should be below 100, and high-density lipoprotein (HDL) should measure 35 or above.
Seven years ago, Pfizer embarked on a bold gambit to pair its cholesterol-lowering drug Lipitor with an experimental pill that dramatically raises levels of HDL, a protein that clears plaque out of the arteries.
Whereas LDL brings cholesterol to the artery wall, where it collects in heart attack-causing plaques, HDL carts it away.
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