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Among them was Endeavour commander Mark Kelly's wife, Gabrielle Giffords, the Arizona politician shot in the head by a gunman in January.
BBC: Shuttle Endeavour launches one last time
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It's also facing a new foe: a political action committee created by former U.S. Rep. Gabrielle Giffords and her husband, Mark Kelly.
CNN: Countdown to new wave in gun violence battle
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Gabrielle Giffords made the trip with her husband, Mark Kelly.
CNN: Gabrielle Giffords visits Newtown
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Kelly and his wife, former Rep. Gabrielle Giffords, D-Arizona, this month launched Americans for Responsible Solutions, which seeks to raise money to counter the influence of the gun lobby.
CNN: Suspect sought in fatal Phoenix office shooting
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Inside the statehouse, Mark Kelly -- the husband of former U.S. Rep. Gabrielle Giffords, the Democratic congresswoman who was shot while meeting with constituents in Arizona in January 2011 -- stressed the importance of universal background checks.
CNN: Will states go where Congress hasn't on gun laws?