Lyle Overbay had a career-best four hits, including a two-run homer, and finished with five RBIs.
He gave up only four hits and two walks over eight innings, striking out eight Tigers.
Pujols homered twice earlier in the game and finished with four hits and three RBIs.
"The first four hits he gives up, only one of them is centered, " Girardi said.
Harvey gave up one run and four hits in seven innings, striking out seven.
Mets starter Rafael Montero allowed four hits in 4 2-3 scoreless innings and struck out three.
Jordy Mercer homered twice and Jose Tabata had four hits, including a two-run shot for the Pirates.
The 38-year-old allowed three runs and four hits in seven innings, with four strikeouts and a walk.
Cano, who had four hits, arrived for the four-game series batting .130 and without an extra-base hit.
Pettitte, who had been pitching in simulated games, allowed one run and four hits over three-plus innings.
He allowed four runs three earned and four hits in five innings and left trailing 4-1.
Hunter had four hits in the opening series at Minnesota, but he hasn't homered yet for the Tigers.
Toronto's Colby Rasmus had a two-run homer among his season-high four hits and robbed Yonder Alonso of a solo shot.
On Monday night, he won 73 percent (16 of 22), led the Bruins with six shots and had four hits.
On Wednesday, he allowed four hits, a walk and a hit batter to lower his ERA to a major-league leading 1.40.
Jackson (1-5), meanwhile, retired 12 of Washington's first 13 batters and allowed two runs and four hits in 5 1-3 innings.
Edgar Gonzalez, competing for a long reliever role with the Astros, gave up three runs and four hits in three innings.
Gonzalez allowed one run and four hits in six innings during the Washington Nationals' 3-1 loss to the New York Mets.
Pettitte (4-3) allowed two runs, four hits and three walks in 4 2-3 innings with five strikeouts, struggling again with his command.
Hughes pitched seven, too, yielding one run and four hits in seven.
"It's hard to win games when you get four hits and don't put any runs on the board, " Yankees outfielder Vernon Wells said.
Sabathia (1-1) gave up four hits and three walks while striking out four in 114 pitches, bouncing back from a dreadful opening-day start.
The Rangers' Derek Holland, who will start for the U.S. on Sunday against Canada, allowed a run on four hits in three innings.
Brandon Belt hit a solo home run, matched his career best with four hits and scored three runs as San Francisco pounded a season-high 17 hits.
Cleveland's starter held a makeshift New York lineup to four hits, and the Yankees wasted a solid outing by David Phelps in losing Monday's doubleheader opener 1-0.
Carlos Corporan homered among his four hits and drove in four runs for the Astros, who were swept by Boston in four games before heading to New York.
Morneau, who had four hits and drove in three runs, doubled in a run, then Michael Saunders walked and Robinson was hit in the foot by a pitch.
But the offense managed just four hits, struck out 12 times and once again failed miserably with runners in scoring position, sending the Mets to their third consecutive defeat.
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