The search for work has become difficult, particularly for young people.
The financial crisis has made it particularly difficult for them to get the loans they need to grow.
The downturn will make it particularly difficult for smaller manufacturing firms that already face high competition at home and abroad.
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Molitor says hard economic times are particularly difficult for people with Type A personalities, especially those who have never experienced failure.
Patents of genetic material make it particularly difficult for not-for-profit organizations, which cannot pay the royalties they would need to access the material.
The technology sector has powerful "network effects" that, some say grant outsize advantages to first movers and make it particularly difficult for competitors to break in.
And those can be particularly difficult for older patients who may have problems hearing and trouble communicating with staff or who deal with dementia and can feel anxious in a strange place, surrounded by strangers.
Benedict gave an insight into the life of the pontiff, describing it as without any kind of privacy, with his time devoted entirely to the Church -- perhaps particularly difficult for a man known for his love of scholarship.
It's a particularly difficult time for tax planning, given the uncertainty surrounding next year's tax rates.
The delay poses particularly difficult challenges for lower-income taxpayers, who rely on these refunds to help pay for basic necessities.
These various assaults come at a particularly difficult time for the Corps as it undergoes a change in its top leadership.
He said he recognised that last year was "particularly difficult" for their customers but said the company had introduced the prices cuts as soon it could.
However, both the empirical and anecdotal evidence clearly suggests that 2011 will be a particularly difficult year for all companies to access bank credit in China.
Another factor may have been that the oil industry in which Lord Browne worked is seen as a particularly difficult place for openly gay people to work, despite recent attempts at firms such as BP to protect and promote equal rights.
This has made the flying experience even more difficult, particularly for the business travelers that provide most of the revenue.
Facebook is particularly difficult to search for personal information, Patton said.
Rather ingeniously, the report's authors have chosen to begin their assessment of women's inequality with the issue of health an area where it is particularly difficult to argue for cultural relativism.
This new standard, combined with U.S. immigration restrictions, is likely to make it far more difficult for Americans, particularly seniors, to find physical therapists in a timely manner in the coming years.
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We have more specific concerns regarding the fact that in the job-cutting cross-hairs are high-profile Merrill Lynch employees, who were instrumental in generating revenues for Bank of America over the particularly difficult 2008-2011 period.
Mr Sissling claimed that "a very significant increase in demand" for unscheduled care, such as in accident and emergency, particularly amongst the elderly, had made it more difficult for health boards to cut their spending in the first half of the year.
That's particularly, I think, difficult for people who are of mixed backgrounds.
The opponents also have said app-hailing could revive concerns about cabbies discriminating against passengers based on their race, whereabouts or destination and could make it difficult for people without smartphones, particularly senior citizens, to get taxis.
Crucially, it provides many jobs for the low-skilled, who can be particularly difficult to place elsewhere.
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Austin is an ideal place for ridesharing, particularly during the upcoming annual South By Southwest conference, when demand for transportation skyrockets and taxis are difficult to find, says Sunil Paul, CEO of SideCar.
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In the context of a bloated and dysfunctional health care system, this significant and immediate alteration in health insurance coverage could be very difficult for many households to absorb financially, particularly if their income falls just above the threshold for federal subsidies to purchase policies in the upcoming health insurance exchanges.
The fact that European schools are struggling is particularly galling because America has also made it more difficult for foreign students to work in the country after graduation, providing what should be an extra opportunity for the Europeans.
One caveat: Estimating population for comparably defined urban areas, particularly in the developing world, can be difficult.
Research confirms that older people living in care homes are particularly at risk of being inappropriately prescribed neuroleptics for behaviour that people find difficult.
Women, especially, seem to have a more difficult time separating themselves from their loyalty for their employer, particularly if they have been with the company for a long time.
"We are coming out of a particularly difficult winter period which saw all trusts across the country struggle for beds, " said Deirdre Thompson, director of nursing at the trust.
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