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Santon is expected to line up at right-back, with World Cup hero Fabio Grosso on the other defensive flank.
BBC: Four debutants in N Ireland team
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The Italians began to take control midway through the half with Fabio Grosso a major threat on the left.
BBC: Rep of Ireland 2-2 Italy
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Italy coach Roberto Donadoni had chosen Panucci ahead of Massimo Oddo at right-back and Gianluca Zambrotta instead of Fabio Grosso on the left.
BBC: Scotland 1-2 Italy
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Italy had almost grabbed the lead after 26 minutes when Fabio Grosso found Corradi with a cross from the left but the header went wide.
BBC: NI beaten by Italy
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Fabio Grosso and Mauro Camoranesi scored their penalties for Italy who won a shoot out to beat France in the final of the 2006 World Cup.
CNN: Spain beat Italy in Euro penalty shoot out
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So Hodgson will have been especially disappointed to see them concede again, from another corner, in first-half injury time after Schwarzer had done brilliantly to turn away Fabio Grosso's shot.
BBC: Juventus 3-1 Fulham
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Italy also had an inexperienced line-up with Gennaro Gattuso and Fabio Grosso the only survivors from the 2006 World Cup final win over France for the game played in front of only 8, 000 spectators.
BBC: Italy 3-0 Northern Ireland
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Left-back Fabio Grosso, who netted the winning penalty in the 2006 World Cup final against France, scored a classy opener against the Bulgarians while his Juve team-mate Claudio Marchisio did well on the left midfield flank.
BBC: Lawrence gets start for Republic