Enterprise announced the outcome of contract discussions on Wednesday, citing the online travel agent's "unacceptably high commission rates" to add its Enterprise brand to the site and a decision by Orbitz to drop National and Alamo from its listings.
On its web site, Social Enterprise UK says the next step is to address the many other tech companies using the phrase.
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The company said it would unveil a master plan for the site, a designated Enterprise Zone, in spring 2013.
The firm is in talks over a new major development at an out of town site, possibly Swansea Enterprise Park or Swansea vale.
The general manager of TAM, Nodar Beridze, was among the delegates who toured the proposed site at the Rotherwas Enterprise Zone on the outskirts of Hereford.
In September it was confirmed some of vacant Deeside site will be used for an enterprise zone, creating 5, 000 jobs.
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The site is part of the Northampton Waterside Enterprise Zone, which was set up in 2011.
Effective April 1, all the listings from Enterprise's brands will be pulled from Orbitz and sister site CheapTickets.
It is considering how to integrate a revenue model that will continue to allow the site to be free, but also put the enterprise in the black.
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"The Heritage Lottery Fund is pleased to be giving its initial support for phase one of wider plans which have the potential to transform the site into a centre for learning, leisure and social enterprise, " she said.
Yesterday, members of the gang which ran the site were sentenced for their roles in the multi-million pound enterprise.
"These are dime-a-dozen lawsuits that are easy to file, " says Ted Frank of the American Enterprise Institute, who predicted the "inevitable free-riding class action" on the Web site Overlawyered.com one day before the first suit was filed in Los Angeles.
Seven people associated with the popular site were indicted this month on charges that they knowingly operated an "international organized criminal enterprise" allowing worldwide sharing of illegally pirated movies, music and other media.
Starting his first enterprise at seven, trading bags of manure, a year later he set up a store on an online auction site, selling items from charity shops.
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