Primary end-points are needed for definitive (Phase 3) proof of efficacy, but they are the most pernicious concept in early stage development.
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At Index Ventures, we have modelled the early stage development process (up to proof of clinical concept) on the presumption that the majority of the risk in a discovery programme is not only unknown but it also unknowable (ahead of testing in man).
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It said the guidance is in an early stage of development and had not been finalised.
Femtosecond lasers are beginning to be used in medicine, although such applications are at an early stage of development.
But it is still a discipline at an early stage of development.
If it seems hard for anyone to make himself heard amid this cacophony, that is largely because e-commerce is at such an early stage of development.
One of the really attractive aspects of investing in the mid-cap area of the market is, we have the opportunity to look for companies that are beyond the trials and travails of early-stage development and infancy.
Small economies at an early stage of financial development tend to dance to their own tunes, Ms. Mehta says.
Venture capital is usually used to refer to investments in young, high growth companies at an early stage of their development.
These animals start breeding during the early stage of grain development.
The Church said Mr Draper was involved "at an early stage in the development of policies and procedures but was replaced when others with greater competence were engaged".
He says his work has been able to show for the first time that the unborn baby engages in complex behaviour from an early stage of its development.
Uses could range from manufacturers engaging focus groups in a much more hands-on way at an early stage of product development to mass customization or individual use of the machines.
In the case of an emerging manager, the exercise is of particular importance since often these firms are at an early stage in their development and lack the staffing and infrastructure that more established firms will have had time to develop.
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For starters, we must dramatically ramp up funding for early-stage clean energy research and development.
She tabled a parliamentary motion raising concerns about the prescriptive nature of the Learning and Development Requirements of the Early Years Foundation Stage.
It also has a drug that is being tested in late-stage clinical trials and another in the early stages of development.
This critical early-stage support offers companies more time to focus on innovation and internal development, allowing them to differentiate themselves from their competitors more effectively.
Bristol-Myers Squibb Co. is conducting several early stage studies on CGRP antagonists and other companies are testing or may begin development of similar compounds as well.
This more collaborative model is being applied to the high-risk innovative early stages of drug discovery, with companies taking on the highly expensive later stage development.
The development of shale-gas reserves beyond North America is still at an early stage.
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In development now is a diagnostic that uses magnetic nanoparticles to detect breast and other cancers at a very early stage.
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