The suicide of a player, Dave Duerson, sent shock waves running through the sport.
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Before taking his life, Duerson asked for his brain to be studied for damage.
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And in 2011, former Chicago Bear safety Dave Duerson committed suicide by shooting himself in the chest.
DeMaurice Smith, while not commenting on the negotiations on Friday, sent a loud and clear message mentioning Duerson.
Alicia Duerson said that several years before he died, her husband had been extremely bright, articulate, gifted.
CNN: Tests reveal former NFL player suffered from brain disease
"Sometimes he would come home with extreme headaches, " said Alicia Duerson during an interview with CNN in February.
CNN: Tests reveal former NFL player suffered from brain disease
Like former NFL player Dave Duerson, Seau apparently shot himself in the chest.
Seau and Duerson reportedly suffered from the same post-concussion, depression-like symptoms Easterling did.
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Duerson's ex-wife said that while playing professionally, the head trauma he bore on the field would become plain after games ended.
CNN: Tests reveal former NFL player suffered from brain disease
John Grimsley, a nine-year NFL veteran who played most of his career with the Houston Oilers was 45, and Duerson was 50.
CNN: Tests reveal former NFL player suffered from brain disease
Duerson had complained of memory loss, and a once in-control man had suffered in recent years from financial setbacks and domestic abuse problems.
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In both cases, Easterling and Duerson exhibited symptoms of repetitive head trauma: memory lapses, anger and deep depression, according to family and friends.
Duerson's case is the first in the CTE narrative in which a player ostensibly took his own life to have his brain studied.
CNN: Tests reveal former NFL player suffered from brain disease
Cumulative hits can lead to chronic traumatic encephalopathy as it did with Chicago Bears safety Dave Duerson, Junior Seau, and many other players.
Before shooting himself, Duerson, a former Chicago Bears defensive back, left a note asking that his brain be studied for signs of trauma.
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"The patterns of the scans are identical to what's seen at autopsy in other people (with CTE), " like Seau, Duerson and Easterling, he said.
Duerson committed suicide, shooting himself in the chest in 2011 and leaving a suicide note that said he wanted his brain studied for possible damage.
Duerson's son Tregg said that the analysis of his father's brain -- the answers to questions about death -- has given the family a measure of closure.
CNN: Tests reveal former NFL player suffered from brain disease
Duerson's death, and specifically the decision to shoot himself in the chest, apparently to avoid damaging his brain tissue, shocked members of his family and the football community.
CNN: Tests reveal former NFL player suffered from brain disease
Duerson began to have trouble forming coherent sentences and spelling.
CNN: Tests reveal former NFL player suffered from brain disease
Duerson suffered a minimum of 10 known concussions during the course of his career, some of them involving loss of consciousness, said Dr. Robert Stern, co-director of the Boston University center.
CNN: Tests reveal former NFL player suffered from brain disease
Seau was one of a string of NFL players -- along with Dave Duerson, Shane Dronett and Ray Easterling -- who took their own lives and were later diagnosed with CTE.
Symptoms that nagged Duerson after he retired from the NFL in 1993 were typical of cases such as Webster and Grimsley, including problems with impulse control, an increasingly short fuse and headaches.
CNN: Tests reveal former NFL player suffered from brain disease
There also have been at least 12 suicides involving former NFL players during the last 25 years, including perennial Pro Bowl defenders Junior Seau and Dave Duerson within the last 14 months.
Seau was one of a string of high-profile NFL players -- along with Dave Duerson, Shane Dronett and Shane Easterling -- who took their own lives and were later diagnosed with CTE.
Dave Duerson, a former NFL safety who shot himself in a similar manner to Seau in 2011, even left in his suicide note a request that his brain be studied for CTE.
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Dave Duerson and Ray Easterling are the others.
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"It is my greatest hope that his death will not be in vain and that through this research his legacy will live on and others won't have to suffer in this manner, " Tregg Duerson said.
CNN: Tests reveal former NFL player suffered from brain disease
The disease has been found in the brains of 33 of 34 former NFL players, including Duerson, studied at the Boston University School of Medicine Center for the Study of Traumatic Encephalopathy as of last May.
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