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If you look at the pharmocokinetic studies, the bioavailability of Subcutaneous MTX gives u almost a dose response linear increase in systemic availability.
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Nevertheless, while the primary endpoint in the PRE-SURGE 2 trial does not appear to have any dose response, as you noted, the endpoints in PRE-SURGE 1 and the secondary endpoints in PRE-SURGE 2 appear to trend slightly better with the 160 mg dose.
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The assumption that Sr-90 and childhood cancer are correlated is best supported for a supralinear dose-response, meaning the greatest per-dose risks are at the lowest doses.
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Change in electrical potential was measured before and after application and a dose-response curve was constructed with R2 value of 99.92%.
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This effect increased at higher doses, suggesting a dose-response association.
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"The absence of a dose-response curve was disappointing, " says Jeffrey Cummings of UCLA. Moreover, he noted that the drug only very modestly reduced levels of a nasty protein called tau in the spinal fluid.
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It has also opened the possibility of single dose vaccines with a long-term immunity response.
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