The dose rate needed to make them work in insects would be too much for people to tolerate, so some more design work is necessary.

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Calabrese says that many poisons follow, instead, a U-shaped curve: The death rate goes down as the dose climbs from zero to a certain small amount, what you could call the optimal exposure.

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All patients must be observed for six hours after their first dose, because Gilenya can cause a drop in heart rate after it is first given.

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The trial also showed a higher rate of muscle side effects for patients getting the top dose than many cardiologists had expected.

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Dr. ANDREW EINSTEIN (Cardiologist, Columbia University): Using beta-blockers or other medications to lower patient's heart rate, which in many cases will chip the radiation dose down by minimizing the number of images which are taken, and matching the technical parameters such that the patient doesn't receive too many x-rays.

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Based on these rates of growth, Norton argued that giving the same total dose of chemotherapy over a shorter period of time would boost the cure rate by limiting the time tumors could regrow between treatments.

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In addition, the FDA recommends that all patients taking Qsymia have their heart rate monitored regularly, in particular when starting the drug or increasing the dose.

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