Mayo itself, BIO pointed out, has licensed a test for a genetic mutation that predicts side-effects for a certain colon-cancer drug.
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The new findings provide more evidence that colon-cancer screening works, but for many people, the tests remain a tough sell, says Leonard Saltz, M.
First, Avastin extended the survival times of colon-cancer patients.
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More than a dozen cancers -- from breast and prostate cancer to pancreatic and colon cancer -- have been linked to America's epidemic of high caloric intake and lack of physical activity.
AstraZeneca's Iressa--which is approved for lung cancer and being tested in colon tumors--is a pill, while Erbitux must be injected.
The drug, Avastin, could hit the market by year-end, joining existing anticancer chemicals and radiation as standard therapy for colon cancer--and it could end up working against other cancers.
However, given their small size (two million of them would be needed to cover a semi-colon) their options are limited - no teeth to grab, no claws for fighting.
That made it 3-0 and ended the afternoon for Colon (3-1), who gave up six hits over 5 1-3 innings his shortest start this season.
"It is the first 'thou shalt not' gene marker in colon cancer, " says Memorial- Sloan-Kettering colon cancer specialist Leonard Saltz, a pioneer in testing Erbitux.
But emerging new gene findings indicate that the high-priced drug may be useless in nearly half of colon cancer patients--and that a simple gene test could allow doctors to predict in advance which patients are likely to benefit.
There is very high certainty from well-designed trials that colon cancer screening, combined with effective follow-up and treatment of abnormal findings, reduces risk of colon cancer death by at least 35 percent and risk of getting colon cancer by 20 percent.
It's also possible that obesity-related cancers that are more common in men -- such as colon, rectal, and kidney cancers -- may simply take longer to manifest than weight-related cancers in women, according to an editorial by Dr. Andrew G.
Colon (3-1) gave up three runs and six hits over 5 1-3 innings in his shortest start this season.
The major killers--tumors of the lung, colon, prostate and pancreas-have resisted targeted therapies (see chart, p. 124).
In December, Pfizer said that a government-funded study testing whether Celebrex could prevent colon polyps instead showed that long-term use of Celebrex doubled the risk of heart attack and stroke.
As in late-stage colon cancer, overall median survival was extended by only a few months.
Cabrera left San Francisco after the season to sign with Toronto, while Oakland re-signed Colon.
He analyzed tumor samples from 415 people who had been operated on for early-stage colon cancer over the last two decades.
And a 2, 700-patient trial unveiled at a conference of cancer doctors in May showed that Avastin did not prevent early-stage colon tumors from returning years later.
Just three months after he retired (after spending more than 40 years as a salesman for an oil company), he was diagnosed with stage-four colon cancer.
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The Genentech drug has slowed down colon tumors, non-small cell lung tumors and now breast tumors, and has opened up more areas for development of future medicines.
Her tummy troubles turned into antibiotic-associated colon inflammation.
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These polyps, if allowed to continue growing may become cancerous in 10 to 15 years, are routinely snipped out of the colon just as pre-cancerous skin growths are removed before the growth can become something dangerous.
Bristol-Myers also said in its letter to Icahn on Thursday that it "has no intention of agreeing to any modifications" to the rights it holds to Erbitux, ImClone's billion-dollar colon cancer drug, which is jointly marketed by the two companies in Canada and the United States.
These drugs--such as Herceptin for breast cancer (Genentech) and Erbitux for colon cancer (Eli Lilly)--were designed to bind to signaling molecules on tumors and disrupt cell growth signals.
Hughes fired eight shutout innings of four-hit ball for his first win of the season, leading the New York Yankees past Colon and the Oakland Athletics 4-2 on Saturday.
Melky Cabrera and Bartolo Colon are both facing 50-game suspensions after testing positive for testosterone usage.
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The guy you step over on the street is costing the system more than anyone else in your life except for the person with end-stage metastatic colon cancer.
Sales of the drug for its main indication, colon cancer, have stalled--partly due to a decision to stop a 2001 study that would have compared the drug to a placebo on top of chemotherapy.
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