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One sufferer of cluster headaches said it was like having a red-hot poker shoved in his eye.
BBC: Headaches and painkillers
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Far worse are migraines and cluster headaches which can be completely debilitating.
BBC: Headaches and painkillers
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Psilocybin has shown promise in treating forms of OCD that are resistant to other therapies, in relieving cluster headaches (a common form of chronic headache) and in alleviating the anxiety experienced by terminally ill cancer patients.
ECONOMIST: LSD