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Chloroquine or the similar compound quinine (an ingredient of tonic water) has been prescribed to prevent cramping.
CNN: What causes leg cramps?
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Resistance to chloroquine emerged in South East Asia, spread, and when it reached Africa, the number of malaria cases rose sharply.
BBC: Can Asia save Africa from drug-resistant malaria?
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The nightmare scenario, however, is a repeat of what took place in the 1980s, with what was then the most commonly used anti-malarial drug, chloroquine.
BBC: Can Asia save Africa from drug-resistant malaria?
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Where chloroquine fails, artemisinin-based combination therapy is usually effective, but these pills are expensive and unfamiliar, so donor help will be important in promoting their use.
ECONOMIST: Malaria: Four horsemen of the Apocalypse? | The
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One is the speed at which chloroquine-resistant parasites have evolved.
ECONOMIST: Malaria: Four horsemen of the Apocalypse? | The
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Growing drug resistance and changing climates means that older drugs like chloroquine have become less effective and so new generations of drugs like Lariam have been recommended as frontline preventative treatment.
BBC: The anti-malaria drug dilemma
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Chloroquine has recently fallen out of favor.
CNN: What causes leg cramps?