With the enzymes trapped inside the pancreas, the gland becomes inflamed, causing excruciating pain.

CNN: Ashcroft remains in intensive care

These particles irritate the artery, making it inflamed and eventually causing the plaque to break apart.

FORBES: Magazine Article

Vioxx, Celebrex and Arcoxia--known as Cox-2 inhibitors--were all designed to ease the pain of inflamed joints without causing ulcers, as older pills like aspirin, ibuprofen and naproxen do.

FORBES: Vioxx, The Sequel