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But scientists from three hospitals in Boston, USA, found that they could temporarily reverse the effects by extracting skin cells from patients whose DNA can't make factor VIII.
BBC: Genetics work eases haemophilia
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Players from both teams gathered at center ice and raised their sticks in a salute to the city and fans who had shouted, "We are Boston" and "USA, USA, " during the game.
WSJ: Sabres beat Bruins 3-2 in shootout
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Dr Tim McAlindon from Boston University Medical School, USA, said the study was a landmark piece of research.
BBC: Supplement 'eases crippling disease'
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"We write down everything, " says Karambir Singh Kang, area director, USA, for Taj Hotels and general manager of the Taj Boston.
CNN: What your hotel knows about you
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Hundreds of people marched down Commonwealth Avenue, chanting "USA" and singing the Red Sox anthem "Sweet Caroline" as they headed toward Boston Common.
WSJ: In suburban Boston, thanks and jubilation