When taking a drug, the benefit-risk profile must be considered.
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Greater accountability, more expeditious decision-making and improved risk-benefit balancing would expend resources more efficiently.
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In recent months, Lilly-backed researchers have shown that prasugrel's risk-benefit profile looks better in diabetics and patients with certain types of heart attacks.
American regulators have recently been taking more of a cost-benefit approach to risk, whereas Europeans are putting more emphasis on precautions, whatever the cost.
The latter group's highly narrow focus on "safety" ignores the fact that because all drugs have side-effects, safety cannot be evaluated in a vacuum but must be part of a risk-benefit judgment.
In fact, while the low-risk patients might not receive any benefit from the test, there is at least some risk from radiation--which is higher for a CT angiogram than a traditional X-ray.
According to the agency, the same risk-benefit analysis does not hold true for restless-leg syndrome.
But it's hard to tell exactly where society comes down on the balancing the risk-benefit scale.
After all, if Vioxx was sold mainly as safer on the stomach, shouldn't the chance of heart risks have radically changed the risk-benefit assessment of the drug?
Like it or not, government is the only institution powerful enough to realign the risk-benefit ratio so that the people's interests are at least borne in mind.
Dr Anne MacGregor, who runs the menopause clinic at St Bartholomew's Hospital in London, feels women are not being given the option of weighing up the risk-benefit ratio themselves.
Given what is likely to be a small magnitude of incremental cardiovascular benefit of high potency statins over low potency statins in reality, a pressing question is how to identify patients for whom the risk-benefit balance for high potency statin treatment is unfavourable.
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Concerned about the entire class of COX-2 inhibitors, the FDA convened a joint session of their Arthritis Advisory Committee and the Drug Safety and Risk Management Advisory Committee on February 16, 17 and 18 to advise the FDA on the risk-benefit profile for these drugs.
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Whistle-blowers undoubtedly face significant risk and must do cost-benefit analysis to decide whether to come forward.
Rowe Price, which should benefit directly from the increasing risk-appetite among both the retail (individual) and institutional investors.
This points to two other defects inherent in defined-benefit plans: All the risk is borne by the taxpayers, and the inability to foresee how much more money will be needed to fully fund the plans makes long-term budget-planning extremely problematical for school boards.
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Companies have also, sensibly, been switching from defined-benefit schemes, under which the company bears the risk of maintaining pension payments, to defined-contribution plans, in which the risk lies with individual pensioners.
Moreover, small-cap equities stand to benefit from improving fundamentals and cheap valuations as investors reassess risk-reward parameters.
Another high-risk group that would benefit from increased HIV testing, according to NICE, is the black African community living in England.
This means that businesses in Denmark stand to benefit from the elimination of exchange-rate risk when dealing with their main trading partners.
However there is no justification for doing this in a way which imposes harsh cuts in benefits from the outset and leaves local authorities - and therefore benefit recipients - vulnerable to further cuts because they have to take the downside risk of any increased expenditure caused by additional benefit claims in year.
The guarantee implied in a typical defined-benefit scheme is not the sort of risk that a company should be expected to incur.
And this leads to the first concrete benefit to an effective risk assessment: business buy-in.
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We would need more evidence that more than these six key, target high-risk groups that are prioritized can benefit.
Smart companies often work with a local partner to benefit from market knowledge, reduce risk, and relieve short-term financial constraints.
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Novartis was informed that the independent Data Monitoring Committee (DMC) overseeing ALTITUDE had recommended stopping the trial because Tekturna was unlikely to show any benefit, and potential safety concerns had been identified in these high-risk patients.
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When the stents are used according to their product labels, the risk seems to be balanced out by their benefit in preventing re-clogging, which might also cause heart attacks.
Not only does it offer investors exposure to the fast-growing South American economies, but it also should benefit from any further deterioration in the dollar and investors' renewed interest in low-risk, consistent business models that generate strong profits and cash flow.
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