Imagine subjecting Shakespeare to a computational process like bioinformatics--not to chop the poor guy into DNA base pairs but to tease out 1, 000-word pieces (or strings) of his plays.

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The genome project, which the government began in 1987, aimed to speed the gene-hunting effort by providing the first full map of all 3 billion base pairs that make up human DNA. (It was not necessary, in this effort, to run through all the pairs on each set of chromosomes, or 6 billion pairs.) And because the base pairs come in only four varieties, they are digital and ideal for computer decoding.

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The 2010 National Medal Science to Jacqueline K. Barton, California Institute of Technology, for discovery of a new property of the DNA helix long-range electron transfer, and for showing that electron transfer depends upon stacking of the base pairs and DNA dynamics.

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